455901-13-0Relevant articles and documents
Sulfonyl-phenyl-ureido benzamidines: A novel structural class of potent antimalarial agents
Leban, Johann,Pegoraro, Stefano,Dormeyer, Matthias,Lanzer, Michael,Aschenbrenner, Andrea,Kramer, Bernd
, p. 1979 - 1982 (2004)
The high throughput in silico screening of a virtual library into the structure of the P. falciparum lactate dehydrogenase (LDH) with the 4SCan technology yielded a series of biphenyl urea compounds. These were chemically optimized to a new structural class of potent antimalarial agents. The compounds did not inhibit plasmodium LDH enough to fully explain their potency. Therefore we conclude that an unknown mode of action may be the cause of the antimalarial activity.
NOVEL SULFAMOYL-PHENYL-UREIDO COMPOUNDS AND THEIR USE AS MEDICAMENT
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Page/Page column 11-12, (2010/08/08)
The present invention relates to novel sulfamoyl-phenyl-ureido compounds having the formula (I) or a physiologically acceptable salt or derivative thereof which are suitable for the therapy of infections caused by protozoa and in particular uncomplicated
Compounds for the treatment of protozoal diseases
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, (2008/06/13)
The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C=O, C=S, C=NH, (C=O)2 or SO2; and to processes for the preparation of these compounds and to their use in the treatment of protozoal diseases and to diseases where the inhibition of intracellular protein-degradation pathways is of benefit.
Compounds for the treatment of protozoal diseases
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, (2008/06/13)
The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C═O, C═S, C═NH, (C═O)2 or SO2; and to processes for the preparation of these compounds and to their use in the treatment of protozoal diseases and to diseases where the inhibition of intracellular protein-degradation pathways is of benefit.
Compounds for the treatment of protozoal diseases
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, (2008/06/13)
Treatment of Protozoan Infections with new diphenylurea derivatives.