455901-41-4

Upstream product

• 631899-72-4 (E)-ethyl-7-((tert-butyldimethylsilyl)oxy)-4-methylhept-4-enoate 
• 455901-51-6 C₃₇H₆₀O₃Si₃ 
• 455901-38-9 (4E)-1-[(4R)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl)](3S,2R)-6-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-3-hydroxy-2-methylhex-4-en-1-one 
• 455901-35-6 (6E)-1-[(4R)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl)](3S,2R)-3-hydroxy-2,6-dimethyl-9-(1,1,2,2-tetra-methyl-1-silapropoxy)non-6-en-1-one 
• 455901-47-0 (E)-(2R,3S)-3,9-Bis-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-non-6-enoic acid methoxy-methyl-amide 
• 455901-39-0 (6E)-(3S,5S,4R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-4-methyloct-6-en-1-yne-3,5-diol 
• 455901-50-5 (E)-(4R,5S)-8-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxy-4-methyl-oct-6-en-1-yn-3-one 
• 455901-49-2 (E)-(2R,3S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-2-methyl-hex-4-enoic acid methoxy-methyl-amide 
• 455901-36-7 (6E)(3S,2R)-9-hydroxy-N-methoxy-2,6-dimethyl-N-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)non-6-enamide 
• 455901-46-9 (E)-(2R,3S)-9-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2,6-dimethyl-non-6-enoic acid methoxy-methyl-amide 
• 455901-48-1 (E)-(2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-9-oxo-non-6-enoic acid methoxy-methyl-amide 
• 185149-00-2 (+/-)-5-tert-butyldimethylsilyloxy-2-methyl-1-penten-3-ol 
• 92829-81-7 (4E)-4-methyl-7-(1,1,2,2-tetramethyl-1-silapropoxy)hept-4-enal 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Relevant academic research and scientific papers

A Cycloaddition Cascade Approach to the Total Synthesis of (-)-FR182877

An asymmetric synthesis of the cytotoxic natural product, (-)-FR182877 (1), has been achieved. Chirality for the entire structure was established using two (4R)-4-benzyl-2-oxazolidinone-mediated boron aldol reactions. A 19-membered macrocarbocycle was syn