455901-49-2

Upstream product

• 1117-97-1 N,0-dimethylhydroxylamine 
• 455901-38-9 (4E)-1-[(4R)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl)](3S,2R)-6-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-3-hydroxy-2-methylhex-4-en-1-one 
• 87770-83-0 (Z)-4-((tert-butyldiphenylsilyl)oxy)but-2-en-1-ol 
• 131380-48-8 (E)-4-(t-butyldiphenylsilyl)oxy-2-butenal 

Downstream Products

• 455901-50-5 (E)-(4R,5S)-8-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxy-4-methyl-oct-6-en-1-yn-3-one 
• 455901-39-0 (6E)-(3S,5S,4R)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-4-methyloct-6-en-1-yne-3,5-diol 
• 455901-51-6 C₃₇H₆₀O₃Si₃ 
• 455901-41-4 (3S,15S,2R,13R,14R)(9Z,6E,11E,16E)-18-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-10-bromo-N-methoxy-2,6,14-trimethyl-N-methyl-3,13,15-tris(1,1,2,2-tetramethyl-1-silapropoxy)octadeca-6,9,11,16-tetraenamide 
• 455901-40-3 C₃₇H₆₃BO₅Si₃ 

Relevant academic research and scientific papers

A Cycloaddition Cascade Approach to the Total Synthesis of (-)-FR182877

An asymmetric synthesis of the cytotoxic natural product, (-)-FR182877 (1), has been achieved. Chirality for the entire structure was established using two (4R)-4-benzyl-2-oxazolidinone-mediated boron aldol reactions. A 19-membered macrocarbocycle was syn

A cascade cycloaddition strategy leading to the total synthesis of (-)-FR182877

A tandem transannular [4+2] cycloaddition strategy is presented for the synthesis of the class of natural products containing FR182877 (1) and hexacyclinic acid (2). As part of this program, a tandem transannular [4+2] cycloaddition reaction has been empl