455957-76-3

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-(2-bromo-5-chlorophenyl)acetate is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique reactivity and properties allow for the construction of complex molecular structures, contributing to the development of new drugs with improved therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical industry, Methyl 2-(2-bromo-5-chlorophenyl)acetate serves as an important building block for the production of agrochemicals. Its versatility in organic synthesis enables the creation of novel compounds with enhanced pesticidal or herbicidal properties, improving crop protection and yield.
Used in Fine Chemicals Synthesis:
Methyl 2-(2-bromo-5-chlorophenyl)acetate is utilized as a versatile intermediate in the synthesis of fine chemicals. Its unique structure allows for the preparation of various ester derivatives and other complex organic molecules, which find applications in fragrances, dyes, and other specialty chemicals.
Used in Organic Synthesis Research:
As a compound with unique reactivity, Methyl 2-(2-bromo-5-chlorophenyl)acetate is employed in organic synthesis research to explore new reaction pathways and develop innovative synthetic methods. Its presence in a wide range of chemical reactions contributes to the advancement of organic chemistry and the discovery of new compounds with potential applications.

Upstream product

• 67-56-1 methanol 
• 81682-38-4 2-(2-bromo-5-chloro-phenyl)acetic acid 

Downstream Products

• 455957-77-4 tert-butyl 4-[4-chloro-2-(2-methoxy-2-oxoethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate 
• 455957-81-0 methyl 2-(2-bromo-5-chlorophenyl)propanoate 
• 1419170-25-4 2-(2-{5-[2-(carboxymethyl)-4-chlorophenyl]thiophen-2-yl}-5-chlorophenyl)acetic acid 
• 1419172-25-0 C₁₅H₂₀BClO₄ 

Relevant academic research and scientific papers

Palladium-Catalyzed [4 + 3] or [2 + 2 + 3] Annulation via C-H Activation and Subsequent Decarboxylation: Access to Heptagon-Embedded Polycyclic Aromatic Hydrocarbons

The construction of a seven-membered ring in the polycyclic aromatic hydrocarbon skeleton remains a notoriously difficult but attractive challenge. Herein a novel palladium-catalyzed [4 + 3] decarboxylative annulation of 2-iodobiphenyls with 2-(2-halophenyl)acrylic acids is reported, which provides an efficient approach for assembling various tribenzo[7]annulenes via a C-H activation and decarboxylation process. Moreover, tribenzo[7]annulenes can be also synthesized via a [2 + 2 + 3] decarboxylative annulation strategy by employing readily available 1,2-halobenzenes, phenylboronic acids, and 2-(2-halophenyl)acrylic acids.

NOVEL COMPOUNDS AND THEIR USE IN THERAPY

The present invention relates to novel chemical compounds formula (I) (C)n-B-(A)m-B-(C)n (I) wherein m is 0 or 1, and n is independently 0, 1, 2 or 3, A, each B and each C are independently selected from phenylene and five-and six-membered heteroaromatic rings, and for a terminal ring B or C also from bicyclic heteroaromatic fused rings having seven to ten ring members, wherein the bond between at least two of the rings A to C may be replaced by a carbonyl group (-CO-), wherein at least two of the rings A to C are substituted with one or two groups R, and wherein each ring A to C further optionally is substituted with one or two groups R1. The compounds are useful in therapy, especially therapy of a mammal suffering from a disease involving misfolded or aggregated forms of proteins.

NOVEL THIOPHENE COMPOUNDS AND METHOD FOR IN VIVO IMAGING

The present invention relates to novel labelled compounds of formula (I) (C)n-B-(A)m-B-(C)n (I) wherein m is 0 or 1, and n is independently 0, 1, 2 or 3, A, each B and each C are independently selected from phenylene and five- and six-membered heteroaromatic rings, and for a terminal ring B or C also from bicyclic heteroaromatic fused rings having seven to ten ring members, wherein the bond between at least two of the rings A to C may be replaced by a carbonyl group ( -CO- ), wherein at least two of the rings A to C are substituted with one or two groups R, and wherein each ring A to C further optionally is substituted with one or two groups R1, for use in imaging amyloid deposits and aggregated protein in living patients. The invention further relates to imaging methods using labelled or unlabelled compounds of formual I and the use of unlabelled compounds in such methods.

2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO [9,10-D] IMIDAZOLES

The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

ACYLATED PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS

Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.