456-05-3Relevant articles and documents
DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A MORPHOLINE MOIETY
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, (2018/11/21)
The disclosure provides compounds of formula (I) or pharmaceutically acceptable salts thereof: The disclosure also provides processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them, and their use
Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors
Liu, Feng,Li, Fengling,Ma, Anqi,Dobrovetsky, Elena,Dong, Aiping,Gao, Cen,Korboukh, Ilia,Liu, Jing,Smil, David,Brown, Peter J.,Frye, Stephen V.,Arrowsmith, Cheryl H.,Schapira, Matthieu,Vedadi, Masoud,Jin, Jian
, p. 2110 - 2124 (2013/05/08)
Protein arginine methyltransferases (PRMTs) play an important role in diverse biological processes. Among the nine known human PRMTs, PRMT3 has been implicated in ribosomal biosynthesis via asymmetric dimethylation of the 40S ribosomal protein S2 and in c
Efficient preparation of biologically important 1,2-amino alcohols
Gupta, Pankaj,Rouf, Abdul,Shah, Bhahwal A.,Mukherjee, Debaraj,Taneja, Subhash C.
, p. 505 - 519 (2013/01/15)
An efficient three-step methodology developed for the preparation of 1,2-amino alcohols. In the first step a rapid coupling between bromoketones and potassium phthalimide in ionic liquid produced-phthalimido ketones in quantitative yields, which is followed by a facile reduction using NaCNBH 3 in acetic acid to give corresponding phthalimido alcohols and finally effecting hydrazinolysis in water at 60C to yield biologically important 1,2-amino alcohols.
