456-44-0 Usage
Uses
Used in Pharmaceutical Industry:
3-Methylbenzyl fluoride is used as a reagent in organic synthesis for its role in the production of pharmaceuticals and other fine chemicals. Its ability to undergo nucleophilic substitution reactions makes it a key component in creating various medicinal compounds.
Used as a Fluorinating Agent:
In the field of organic chemistry, 3-Methylbenzyl fluoride serves as a fluorinating agent, aiding in the synthesis of organic compounds that require the introduction of fluorine atoms for specific chemical properties or reactivity.
Used in Industrial Processes:
3-Methylbenzyl fluoride is also utilized as a solvent in some industrial processes, where its unique chemical properties contribute to the efficiency or effectiveness of certain manufacturing procedures.
Safety Note:
It is crucial to handle 3-Methylbenzyl fluoride with care due to its toxic nature. Exposure can lead to skin and eye irritation, as well as respiratory issues if inhaled. Proper safety measures and personal protective equipment are essential when working with 3-Methylbenzyl fluoride.
Check Digit Verification of cas no
The CAS Registry Mumber 456-44-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 456-44:
(5*4)+(4*5)+(3*6)+(2*4)+(1*4)=70
70 % 10 = 0
So 456-44-0 is a valid CAS Registry Number.
456-44-0Relevant academic research and scientific papers
9-Borabicyclo[3.3.l]nonane-induced Friedel-Crafts benzylation of arenes with benzyl fluorides
Guo, Jing,Bamford, Karlee L.,Stephan, Douglas W.
supporting information, p. 5258 - 5261 (2019/06/07)
Friedel-Crafts benzylation of arenes with benzyl fluorides using 9-borabicyclo[3.3.l]nonane (9-BBN) as a mediator has been developed. This provides a simple and cheap route to the activation of C-F bonds to synthesize 1,1-diarylmethanes in good to excellent yields (up to 98%) under mild conditions. Functional group tolerance and the mechanism are considered.
Novel Synthesis of 2,2,2-Trifluoroethyl Compounds from Homoallylic Alcohols: A Copper(I) Iodide-initiated Trifluoromethyl-Dehydroxylation Process
Duan, Jian-Xing,Chen, Quing-Yun
, p. 725 - 730 (2007/10/02)
Benzyl, prop-2-enyl and allyl chlorodifluoroacetates 3a, bromodifluoroacetates 3b or fluorosulfonyldifluoroacetates 3c, when decomposed in the presence of 1 equivalent of copper(I) iodide at an appropriate temperature in dimethylformamide, gave the corresponding trifluoromethyl derivatives in good to excellent yields.The products can also be obtained directly by ester exchange of XCF2CO2Et (X = FSO2, Cl, Br) 6 and the corresponding alcohols in the presence of KF and CuI.A trifluoromethylation-dehydroxylation mechanism, initiated by CuI, is proposed.
