4561-10-8

Basic information

• Product Name: H-GLU(OBZL)-OBZL HCL
• Synonyms: H-GLU(OBZL)-OBZL HCL;L-GLUTAMIC ACID-ALPHA,GAMMA-DIBENZYL ESTER HYDROCHLORIDE;L-Glutamic acid dibenzyl ester hydrochloride;H-Glu(Obzl)-Obzl hydrochloride;L-GLUTAMIC ACID-A,Y-DIBENZYLESTER HYDROCHLORIDE;L-GLUTAMIC ACID BIS(PHENYLMETHYL) ESTER HYDROCHLORIDE;(2S)-2-aminoglutaric acid dibenzyl ester hydrochloride;bis(phenylmethyl) (2S)-2-azanylpentanedioate hydrochloride
• CAS NO: 4561-10-8
• Molecular Formula: C₁₉H₂₂NO₄*Cl
• Molecular Weight: 363.84
• Mol File: 4561-10-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 102.0 to 106.0 °C
• Boiling Point: 453.5 °C at 760 mmHg
• Flash Point: 165.6 °C
• Appearance: White/Powder
• Vapor Pressure: 2.06E-08mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: H-GLU(OBZL)-OBZL HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-GLU(OBZL)-OBZL HCL(4561-10-8)
• EPA Substance Registry System: H-GLU(OBZL)-OBZL HCL(4561-10-8)

Safety Data

• RTECS: MA0885000
• Hazardous Substances Data: 4561-10-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 4561-10-8 differently. You can refer to the following data:
1. L-Glutamic acid dibenzyl ester hydrochloride oxalate used as a intermediate in pharmaceutical and chemical synthesis. Also used in medicine research.
2. H-Glu(Obzl)-Obzl HCl

InChI:InChI=1/C19H21NO4.ClH/c20-17(19(22)24-14-16-9-5-2-6-10-16)11-12-18(21)23-13-15-7-3-1-4-8-15;/h1-10,17H,11-14,20H2;1H/t17-;/m0./s1

Upstream product

• 56-86-0 L-glutamic acid 
• 100-51-6 benzyl alcohol 
• 80963-14-0 dibenzyl N-tert-butyloxycarbonyl-L-glutamate 
• 2419-94-5 Boc-Glu 

Downstream Products

• 18791-58-7 N-[N-(N-benzyloxycarbonyl-L-leucyl)-L-valyl]-L-glutamic acid dibenzyl ester 
• 302941-54-4 dibenzyl (S)-2-isocyanatopentanedioate 
• 60219-06-9 dibenzyl methotrexate 
• 79974-10-0 N-methylamino>benzoyl>-L-γ-glutamyl>-L-glutamic acid tribenzyl ester 
• 79974-13-3 N-methylamino>benzoyl>-L-α-glutamyl>-L-glutamic acid tribenzyl ester 
• 157896-18-9 (S)-2-((S)-4-{4-[((5R,6S)-2-Amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-benzyloxycarbonyl-butyrylamino)-pentanedioic acid dibenzyl ester 
• 2768-50-5 dibenzyl L-glutamate 
• 97656-57-0 N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-L-glutamic acid dibenzyl ester 
• 59524-71-9 t-butoxycarbonyl-L-alanyl-L-glutamic acid dibenzyl ester 

Relevant articles and documents

SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders as well as other disorders.

Green preparation method of N-substituted-L-pyroglutamate

The invention provides a green preparation method of N-substituted-L-pyroglutamate. The method comprises the steps as follows: L-glutamic acid diester hydrochloride (III) is prepared from L-glutamic acid (II) as a starting material in the presence of an acidic reagent by an esterification reaction; then, L-glutamic acid diester hydrochloride (III) is subjected to N-substituted protective reactionwith an N-substituent protective reagent with a one-pot method in the presence of a base and a solvent, an N-substituted protective group is introduced, heating is performed for dealcoholization cyclization in molecules, and N-substituted-L-pyroglutamate as shown in the formula (I) is obtained. The method has the advantages of cheap and easily available raw materials, classic reaction types, shortprocess route, simple and convenient operation, small waste water amount, green and environment-friendly production process, high reaction yield and low product cost. 5R-benzyloxyaminopiperidine-2S-carboxylate, 5R-benzyloxyaminopiperidine-2S-formate ethanedioate and avibactam can be prepared from N-substituted-L-pyroglutamate as shown in the formula (I).

Study on synthesis, characteristics and catalysis properties of novel chiral metal complexes catalysts for 1,3-dipolar cycloaddition reactions of nitrone with electron-rich alkene

As a new class of potential catalysts for 1,3-dipolar cycloaddition reactions, fourteen L-amino acid Schiff base Cu(II) and Ti(IV) complexes were synthesized, characterized, and evaluated for their catalytic activities in the reaction between C, N-diphenylnitrone and electron-rich ethyl vinyl ether under both homogeneous and in situ conditions. The methods for preparation and utilization of the catalysts were elucidated in detail, and the results of the catalytic reactions were described and discussed as well. Excellent reaction results were found in the presence of some catalysts (20 mol%) with > 90% endo-isoazolidines produced, compared with predominantly exo-isoazolidine produced without a catalyst. In addition, the reaction rate is found to be enhanced remarkably by a Cu(II) complex Schiff base catalyst at room temperature.