45669-18-9

Basic information

• Product Name: 3,4-dibromodihydrofuran-2,5-dione
• Synonyms: 2,5-Furandione, 3,4-dibromodihydro-
• CAS NO: 45669-18-9
• Molecular Formula: C₄H₂Br₂O₃
• Molecular Weight: 257.8649
• Mol File: 45669-18-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 330.8°C at 760 mmHg
• Flash Point: 153.9°C
• Density: 2.541g/cm³
• Vapor Pressure: 0.000162mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: 3,4-dibromodihydrofuran-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dibromodihydrofuran-2,5-dione(45669-18-9)
• EPA Substance Registry System: 3,4-dibromodihydrofuran-2,5-dione(45669-18-9)

Safety Data

• Hazardous Substances Data: 45669-18-9(Hazardous Substances Data)

Upstream product

• 108-31-6 maleic anhydride 
• 77220-06-5 2,5-bis<(trimethylsilyl)oxy>furan 
• 526-78-3 2,3-dibromosuccinic acid 

Downstream Products

• 526-78-3 2,3-dibromosuccinic acid 
• 5926-51-2 bromomaleic anhydride 
• 10035-10-6 hydrogen bromide 
• 22221-93-8 iso-β-benzoyl-acrylic acid-dibromide 

Relevant articles and documents

NOVEL CONNECTED BODY AND USE THEREOF IN SPECIFIC CONJUGATION BETWEEN BIOMOLECULE AND DRUG

PROBLEM TO BE SOLVED: To provide: a method for producing a connected body; a method for using the connected body in the production of a uniform conjugate; and a method for applying the conjugate in the treatment of cancer, infectious diseases, and autoimmune diseases. SOLUTION: A novel connected body is provided that includes a 2,3-di-substituted succinic acid group or a 2-mono-substituted or 2,3-di-substituted fumaric acid or maleic acid (trans (E)- or cis (Z)-butenedioic acid) group for conjugating 2 or more compounds/cytotoxic agents per connected body with a cell-binding molecule by specifically bridge-linking to a pair of thiol on the cell-binding molecule. The connected body is exemplified by the following general formula. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

NOVEL LINKERS AND THEIR USES IN SPECIFIC CONJUGATION OF DRUGS TO A BIOLOGICAL MOLECULE

The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)- butenedioic) group for conjugation of two or more compounds/cytotoxic agents per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.

Halogenated polyol-ester neutralization agent

Haze-free reactive flame retardant halo polyols are made by reacting (a) a halogen containing cyclic acid anhydride (e.g. tetrabromophthalic anhydride), (b) an aliphatic polyol, e.g. diethylene glycol, and (c) an epoxide, e.g. propylene oxide, and including potassium salt of fatty acids (e.g. potassium acetate) in the reaction mixture in an amount at least sufficient to neutralize residual sulfuric acid that is usually present in the halogen containing cyclic acid anhydride.