45675-76-1

Usage

Chemical structure

Bicyclic with a ketone functional group

Type of compound

Azabicyclo[3.2.1]octan-6-one

Role

Key intermediate in the synthesis of tropane alkaloids

Pharmacological properties

Various, including medical applications

Applications

a. Production of pharmaceuticals (e.g., atropine, scopolamine)
b. Insecticides
c. Herbicides

Industry

Chemical industry

Reactivity

Versatile

Unique feature

Unique structure that allows for a wide range of applications

Upstream product

• 114725-08-5 1-ethoxycarbonylmethyl-piperidine-3-carboxylic acid ethyl ester 
• 108-88-3 toluene 

Downstream Products

• 79856-38-5 1-cinnamyl-1-azoniabicyclo<3.2.1>octan-6-one bromide 
• 50742-85-3 1-(3-phenylprop-2-ynyl)-1-azoniabicyclo<3.2.1>octan-6-one bromide 
• 149969-11-9 Z-(+/-)-1-Azabicyclo[3.2.1]octan-6-one, O-(3-phenyl-2-propynyl)oxime oxalate 
• 115595-01-2 (1S,5S,6S)-1-Aza-bicyclo[3.2.1]octane-6-carboxylic acid 
• 50742-87-5 cis-7-(1-phenylprop-2-enylidene)-1-azabicyclo<3.2.1>octan-6-one 
• 50742-88-6 trans-7-(1-phenylprop-2-enylidene)-1-azabicyclo<3.2.1>octan-6-one 
• 50742-86-4 7-(1-phenylpropa-1,2-dienyl)-1-azabicyclo<3.2.1>octan-6-one 
• 279-92-5 1-aza-bicyclo[3.2.1]octane 
• 80851-96-3 1-piperidin-3-yl-ethanone 
• 162184-60-3 (5S)-1-azabicyclo[3.2.1]octane-6-one 
• 162184-58-9 (5R)-1-azabicyclo[3.2.1]octane-6-one 

Relevant academic research and scientific papers

Oxadiazoles useful in the treatment of senile dementia

A class of novel oxadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring, and substituted on the other ring carbon atom with a substituent of low lipophilicity; are potent muscarinic agonists, and have good CNS penetrability. The compounds are therefore useful in the treatment of neurological and mental illnesses.

THIADIAZOLES USEFUL IN THE TREATMENT OF SENILE DEMENTIA

A class of novel thiadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring system, and substituted on the other ring carbon atom with a substituent of low lipophilicity, or a hydrocarbon substituent; are potent muscarinic agonists, and have good CNS penetrability. The compounds are therefore useful in the treatment of neurological and mental illnesses, and are also of benefit in the treatment of severe painful conditions.

Substituted Benzamides with Conformationally Restricted Side Chains. 5. Azabicyclo Derivatives as 5-HT4 Receptor Agonists and Gastric Motility Stimulants

The syntheses of benzamides containing azabicyclo side chains and their 5-HT4 receptor agonist and 5-HT3 receptor antagonist properties are described.These compounds were designed to mimic higher energy conformations of quinol