45698-21-3Relevant academic research and scientific papers
Process safety evaluation of a magnesium-iodine exchange reaction
Reeves, Jonathan T.,Sarvestani, Max,Song, Jinhua J.,Tan, Zhulin,Nummy, Laurence J.,Lee, Heewon,Yee, Nathan K.,Senanayake, Chris H.
, p. 1258 - 1262 (2006)
An unexpected highly exothermic decomposition was observed during routine safety analysis of the magnesium-iodine exchange reaction of 2-iodo-4-fluorotoluene (3) with commercially available i-PrMgCl (2.0 M solution in THF). When the reaction mixture was scanned in an adiabatic calorimeter with the use of a 2 °C/min temperature ramp, a rapid exothermic decomposition with an onset temperature of approximately 80 °C was observed. The system temperature rapidly rose to 210 °C at a peak rate of 200 °C/min. Subsequent testing of three simplified substrates showed the same type of exothermic decomposition for all cases. Control experiments indicated that the decomposition requires both aryl iodide and i-PrMgCl (or arylMgCl and i-PrI). While the onset temperatures for all cases studied were generally well above the typical operating temperature for these reactions (0-10 °C), it is nonetheless important to cautiously evaluate these types of processes and install proper engineering controls for analogous decomposition events.
Method of preparing organomagnesium compounds
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Figure 3, (2010/02/14)
The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts - LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.
