457-50-1

Usage

Uses

Used in Pharmaceutical Research and Development:
2,2,2-Trifluoro-N-(pyridin-2-yl)acetamide is employed as a key intermediate in the synthesis of various pharmaceuticals, particularly those with antihypertensive and anti-inflammatory properties. Its role in the development of these drugs is crucial for managing blood pressure and reducing inflammation, respectively.
Used in Enzyme Inhibition:
In the field of biochemistry, 2,2,2-trifluoro-N-(pyridin-2-yl)acetamide is used as an inhibitor of the enzyme PDE7 (Phosphodiesterase 7). This enzyme plays a significant role in various biological processes, and its inhibition can have potential therapeutic effects in the treatment of diseases.
Used in the Treatment of Neurological Disorders:
2,2,2-Trifluoro-N-(pyridin-2-yl)acetamide is used as a potential therapeutic agent for neurological disorders. Its ability to inhibit PDE7 may contribute to the regulation of cellular processes involved in these conditions, offering a new avenue for treatment.
Used in the Treatment of Autoimmune Diseases:
2,2,2-trifluoro-N-(pyridin-2-yl)acetamide is also being explored for its potential use in the treatment of autoimmune diseases. The modulation of PDE7 activity by 2,2,2-trifluoro-N-(pyridin-2-yl)acetamide may help in controlling the immune response and reducing the symptoms associated with these conditions.
Used in Drug Discovery:
2,2,2-Trifluoro-N-(pyridin-2-yl)acetamide is used as a valuable tool in drug discovery, where its unique structure and properties can be leveraged to design and develop new therapeutic agents. Its versatility in interacting with various biological targets makes it an essential component in the search for novel drugs.

Upstream product

• 504-29-0 2-aminopyridine 
• 407-25-0 trifluoroacetic anhydride 
• 76-05-1 trifluoroacetic acid 
• 383-63-1 ethyl trifluoroacetate, 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 402477-82-1 3-(4'-methylbiphenyl4-yl)-3-{3-[2-(2-imino-2H-pyridin-1-yl)ethoxy]benzoylamino}propionic acid 
• 402477-83-2 3-(4'-methyl biphenyl-4-yl)-3-{3-[2-(2-imino-2H-pyridin-1-yl)ethoxy]benzoylamino}propionic acid trifluoroacetate 
• 402477-78-5 3-(4'-chlorobiphenyl-4-yl)-3-{3-[2-(2-imino-2H-pyridin-1-yl)ethoxy]benzoylamino}propionic acid 
• 402477-79-6 3-(4'-chlorobiphenyl-4-yl)-3-{3-[2-(2-imino-2H-pyridin-1-yl)ethoxy]benzoylamino}propionic acid trifluoroacetate 
• 402477-74-1 3-(3'-fluorobiphenyl4-yl)-3-{3-[2-(2-imino-2H-pyridin-1-yl)ethoxy]benzoylamino}propionic acid 
• 402477-80-9 3-(3'-chlorobiphenyl4-yl)-3{3-[2-(2-imino-2H-pyridin-1-yl)ethoxy]benzoylamino}propionic acid 
• 402477-81-0 3-(3'-chlorobiphenyl-4-yl)-3{3-[2-(2-imino-2H-pyridin-1-yl)ethoxy]benzoylamino}propionic acid trifluoroacetate 
• 402477-59-2 methyl 4{2-[2-(2,2,2-trifluoroacetylimino)-2H-pyrid in-1-yl]ethoxy}benzoate 
• 1453496-35-9 N-(benzoyloxy)-N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetimidamide 
• 1453497-29-4 C₂₀H₁₆ClF₃N₄O₃S 
• 1453497-33-0 C₂₀H₁₄ClF₃N₄O₃ 
• 1453497-40-9 C₂₀H₁₆ClF₃N₄ 
• 1453497-48-7 C₂₁H₁₈ClF₃N₄O 
• 1453497-62-5 C₁₉H₂₀ClF₃N₄ 

Relevant academic research and scientific papers

A Chemoselective N-Arylation Reaction of 2-Aminopyridine Derivatives with Arynes

A chemoselective N-arylation reaction of 2-aminopyridine derivatives with arynes in good to excellent yields has been described. The N-arylation products could be further applied to the facile construction of benzoisoquinuclidines and isoquinuclidines as

Mesoionic pyrido[1,2-a]pyrimidinones: A novel class of insecticides inhibiting nicotinic acetylcholine receptors

A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species, particularly hemiptera and lepidoptera. Mode-of-action studies showed that they act on nicotinic acetylcholine receptors (nAChRs) primarily as inhibitors. Here we report the discovery, evolution, and preparation of this class of chemistry. Our efforts in structure–activity relationship elucidation and biological activity evaluation are also presented.

METHOD FOR PRODUCING PEST CONTROLLING AGENT

To supply a derivative having a 2-acyliminopyridine structure and being represented by the following formula (I) in an amount required as a pest control agent stably and at a low cost, provided is a method comprising the steps of: acylating an amino group at position 2 of a compound represented by formula (A) by use of an acylating agent, to thereby produce a compound represented by formula (B); and further alkylating a nitrogen atom at position 1 of the compound represented by formula (B): [where Ar represents a phenyl group or a 5-to 6-membered heterocycle, R1 represents a C1-6 alkyl group, and Y represents a hydrogen atom; a halogen atom; a hydroxyl group; a C1-6 alkyl group which may be substituted with a halogen atom; a C1-6 alkyloxy group which may be substituted with a halogen atom; a cyano group; a formyl group; or a nitro group].

Pest control composition including novel iminopyridine derivate

Provided is a pest control composition containing a novel iminopyridine derivative and other pest control agents. Provided is a pest control composition containing an iminopyridine derivative represented by the following Formula (I) and at least one of other pest control agents: [in the formula, Ar represents a 5- to 6-membered heterocycle which may be substituted, A represents a heterocycle having a 5- to 10-membered unsaturated bond including one or more nitrogen atoms, and has an imino group substituted with an R group at a position adjacent to the nitrogen atom present on the cycle, Y represents hydrogen, halogen and the like, and R represents any one of groups represented by the following Formulae (a) to (e), (y) or (z)].

Nitrogen-containing hetercyclic derivate having 2-imino group and pest control agent including the same

Provided is a nitrogen-containing heterocyclic derivative having a 2-imino group, which is represented by the following Formula (I). [in the formula, Ar represents a phenyl group which may be substituted, a 5- to 6-membered heterocycle which may be substituted, or a 4- to 10-membered heterocycloalkyl group, A represents a heterocycle having a 5- to 10-membered unsaturated bond including one or more nitrogen atoms, and has an imino group substituted with an R group at a position adj acent to the nitrogen atom present on the cycle, Y represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1 to C6 alkyl group which may be substituted with a halogen atom, a C1 to C6 alkyloxy group which may be substituted with a halogen atom, a cyano group, or a nitro group, and R represents any one of groups represented by the following Formulae (a) to (e), (y) or (z).]

PEST CONTROL AGENT

Specific amine derivatives have been found to possess excellent activities as pest control agents.

IMINE COMPOUND

An imine compound represented by the formula: wherein A represents a heterocyclic group; R1, R2, an R3 each represent a hydrogen atom, a halogen atom, a C1-10 alkyl group optionally substituted with an aryl grou

Unexpected formation of N,N-disubstituted formamidines from aromatic amines, formamides and trifluoroacetic anhydride

An intriguing selectivity towards the formation of the formamidine was observed upon the reaction of an amine with sodium hydride and trifluoroacetic anhydride in dimethyl formamide. Various aromatic amines were reacted with a series of N,N-disubstituted formamides as a solvent under the influence of trifluoroacetic anhydride to thoroughly probe this behaviour. A trend in selectivity is discussed and a proposed mechanism for the reaction is also presented.

Microwave-promoted trifluoroacetylation of amines with TiO(CF3CO2)2

Conversion of amines to their corresponding trifluoroacetamides was performed with TiO(CF3CO2)2 in a conventional microwave oven under solvent-free conditions in excellent yields.

Synthesis of Three pyridines

The synthesis of o-, m, and p-pyridine by diborane/tetrahydrofuran reduction of the corresponding trifluoroacetamide is described.The yields were 52 percent, 83 percent, and 76 percent, respectively.The synthesis, in 53 percent yield, of 2,2,2-trifluoro-N-(4-pyridyl)acetamide is also described.