457050-40-7Relevant academic research and scientific papers
An improved methodology for the preparation of 4,7-dimethoxy-1H- benzimidazole, a key intermediate in the synthesis of 1-alkyl-1H-benzimidazole- 4,7-diones
Taleb, Abbass,Alvarez, Frederic,Nebois, Pascal,Walchshofer, Nadia
, p. 111 - 114 (2006)
We reported an optimized process for the preparation of key intermediate, 4,7-dimethoxy-1H-benzimidazole, from commercially available 1,4-dimethoxybenzene (Overall yield 52%). We successfully applied this methodology to an improved synthesis of 1-benzyl-1
A diels-alder strategy for the building of imidazo[4,5-g]quinoline-4,9- dione derivatives
Alvarez, Frederic,Taleb, Abbas,Gentili, Jacques,Nebois, Pascal,Terreux, Raphael,Domard, Monique,Thozet, Alain,Merle, Daphne,Fillion, Houda,Walchshofer, Nadia
, p. 1903 - 1908 (2007/10/03)
Benzimidazole-4,7-diones 3a and 3b were synthesized and submitted to hetero Diels-Alder reactions with azadienes 4 and 5 to afford imidazo[4,5-g]quinoline- 4,9-diones 6-9. The structure of the latter was assigned by X-ray diffraction, 1H NMR NO
Benzimidazole-4,7-diones as inhibitors of protozoal (Toxoplasma gondii) purine nucleoside phosphorylase
Alvarez, Frédéric,Ghérardi, Arnaud,Nebois, Pascal,Sarciron, Marie-Elizabeth,Pétavy, Anne-Fran?oise,Walchshofer, Nadia
, p. 977 - 979 (2007/10/03)
Benzimidazole-4,7-diones derivatives substituted at 1- and/or 2-position have been synthetized and tested as inhibitors of purine nucleoside phosphorylase (PNP), isolated from two strains of Toxoplasma gondii (RH and ME 49). They were identified as inhibi
