457097-60-8Relevant academic research and scientific papers
A concise synthesis of silanediol-based transition-state isostere inhibitors of proteases.
Organ, Michael G,Buon, Christophe,Decicco, Carl P,Combs, Andrew P
, p. 2683 - 2685 (2002)
[reaction: see text] An efficient synthesis of silanediol-based transition-state inhibitors of proteases is described. A new convergent synthesis has been optimized by using a two-step sequence of hydrosilylation followed by the addition of a silyllithio
