457603-47-3

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 121823-95-8 methyl 7-iodohept-2-ynoate 
• 607388-37-4 [2-(4-chlorobutyl)-[1,3]dioxolan-2-yl]acetic acid methyl ester 
• 105-45-3 acetoacetic acid methyl ester 
• 607388-38-5 {2-[4-((S)-1-phenylethylamino)butyl]-[1,3]dioxolan-2-yl}acetic acid methyl ester 
• 113994-81-3 methyl 7-iodo-3-oxoheptanoate 

Downstream Products

• 881012-43-7 2-[1-(1(S)-phenylethyl)piperidin-2-ylidene]propionic acid methyl ester 
• 881012-42-6 2-methyl-3-oxo-7-(1(S)-phenylethylamino)heptanoic acid methyl ester 

Relevant academic research and scientific papers

Chiral heterocyclic β-enamino esters: Convenient synthesis and diastereoselective reduction

The preparation of chiral pyrrolidine and piperidine β-enamino esters starting from ω-halogeno β-keto esters, their diastereoselective reduction and the subsequent cleavage of the chiral auxiliary are described.

A short and convenient synthesis of chiral heterocyclic β-enamino esters from halogeno acetylenic esters

An efficient synthesis of chiral pyrrolidine and piperidine enamino esters is described in one step from methyl halogeno alcynoate and (S)-1-phenylethylamine or (S)-phenylglycinol.