457604-25-0Relevant academic research and scientific papers
Lipase-catalyzed highly enantioselective kinetic resolution of racemic α-hydroxy butenolides
Kirschner, Anett,Langer, Peter,Bornscheuer, Uwe T.
, p. 2871 - 2874 (2004)
The cyclization of 1,3-bis(trimethylsilyloxy)-1,3-butadienes 2a-e with oxalyl chloride afforded functionalized γ-alkylidene butenolides 3a-e while their subsequent hydrogenation gave racemic α-hydroxy butenolides 4a-e. These were subjected to lipase-catalyzed kinetic resolutions in a biphasic mixture composed of phosphate buffer and 20% toluene. The highest enantioselectivities (E = 67-100) were achieved using lipase from Burkholderia cepacia (Amano PS).
Synthesis of γ-lactones and ascorbic acid analogues by diastereoselective hydrogenation of α-hydroxy-γ-alkylidenebutenolides
Langer, Peter,Saleh, Nehad N.R.,Koehler, Valentin
, p. 1566 - 1572 (2002)
The cyclization of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with oxalyl chloride afforded functionalized γ-alkylidene-α-hydroxybutenolides, which were transformed into cis-configured γ-lactones by diastereoselective hydrogenation. Wiley-VCH Verlag GmbH,
