457628-37-4

Usage

Uses

Used in Pharmaceutical Industry:
5,8-difluoro-2H-1-Benzopyran is used as an anti-inflammatory and analgesic agent for its potential to alleviate inflammation and pain. Its biological activity makes it a promising candidate for the development of new medications.
Used in Neurodegenerative Disease Treatment:
5,8-difluoro-2H-1-Benzopyran is used as an acetylcholinesterase inhibitor for its potential to treat neurodegenerative diseases. By inhibiting the enzyme acetylcholinesterase, it may help slow down the progression of diseases like Alzheimer's.
Used in Analytical Chemistry:
5,8-difluoro-2H-1-Benzopyran is used as a fluorescent probe for the detection of metal ions. Its ability to fluoresce in the presence of certain metal ions makes it a valuable tool in analytical chemistry for environmental and biological monitoring.

Upstream product

• 457628-36-3 1,4-difluoro-2-(prop-2-yn-1-yloxy)benzene 
• 672946-37-1 2,4-difluoro-1-(prop-2-yn-1-yloxy)benzene 

Downstream Products

• 944950-67-8 5,8-difluoro-2H-chromene oxide 

Relevant academic research and scientific papers

A Unique Synthesis of 5,8-Difluoro-2 H -chromene Using Silicone Oil as a Solvent

A significantly improved synthesis of 5,8-difluoro-2H-chromene 1 using silicone oil as the reaction solvent is described. The new method eliminated the tedious workup and large quantity of waste produced via conventional methods. To our best knowledge, th

NON-NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS

Compounds of the formula Z: where; A is CH or N; R1 is a substituent to a carbon atom in the ring containing A selected from -S(=O)pRa, where Ra is -C1-C4 alkyl, -ORx, -NRxRx, -NHNRxRx, - NHNHC(=O)ORx, -NRxOH; -C(=O)-Rb, where Rb is -CT-C4-alkyl, ORx, -NRxRx, -NHNRxRx, -NHC1-C3-alkyl-C(=O)Orx -NRxRc, where Rc is H, C1-C4 alkyl, -NRxRx; -C(=0)Rd, -CN, S(=O)pRx where Rd is Rd is C1-C4-alkyl, -ORx, -NRxRx C1-C3-alkyl-O-Cl-C3alkylC(=O)ORx, -C1-C3-alkyl-COORx; -C1-C3alkyl-OH or C1-C4 alkyl ethers or esters thereof (O-Cl-C3alkyl)q-O-Rx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C1-C4 alkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is -0-, -S(=O),- or -CH2-, where r is 0, 1 or 2; R3-R7 are substituents as defined in the specification; X is -(CR8R8')n-D-(CR8R8')m-; D is a bond, -NR9-, -0-, -S-, -S(=0)- or -S(=0)2-; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIV antivirals.

Non-nucleoside reverse transcriptase inhibitors

Compounds of the formula I: where; R1 is O, S; R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)urea bond; R3 is H, C1-C3 alkyl, R4-R7 are independently selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, haloC1-C6 alkyl, C1-C6 alkanoyl, haloC1-C6 alkanoyl, C1-C6 alkoxy, haloC1-C6 alkoxy, C1-C6 alkyloxy-C1-C6 alkyl, haloC1-C6 alkyloxy-C1-C6 alkyl hydroxy-C1-C6 alkyl, amino-C1-C6 alkyl, carboxy-C1-C6 alkyl, cyano-C1-C6 alkyl, amino, carboxy, carbamoyl, cyano, halo, hydroxy, keto; X is —(CHR8)n-—D—(CHR8)m—; D is —NR9—, —O—, —S—, —S(═O)— or —S(═O)2—; R8 is independently H, C1-C3 alkyl, halo substitutedC1-C3alkyl; R9 is H, C1-C3 alkyl; n and m are independently 0, 1 or 2; and prodrugs and pharmaceutically acceptable salts thereof, have utility as inhibitors of HIV-1 reverse transcriptase, particularly drug escape mutants.