457639-26-8

Basic information

• Product Name: 2,5-DiMethyl Celecoxib
• Synonyms: 4-[5-(2,5-DiMethylphenyl)-3-(trifluoroMethyl)-1H-pyrazol-1-yl]benzenesulfonaMide;2,5-DiMethyl-celecoxib DMC;2,5-Dimethylcelecoxib 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide;2,5-DiMethyl Celecoxib;4-[5-(2,5-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide
• CAS NO: 457639-26-8
• Molecular Formula: C₁₈H₁₆F₃N₃O₂S
• Molecular Weight: 395.3987496
• Product Categories: Sulfur & Selenium Compounds;Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 457639-26-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 516.7±60.0 °C(Predicted)
• Appearance: white to beige/
• Density: 1.40±0.1 g/cm3(Predicted)
• Storage Temp.: room temp
• Solubility: DMSO: soluble20mg/mL, clear
• PKA: 9.67±0.10(Predicted)
• CAS DataBase Reference: 2,5-DiMethyl Celecoxib(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DiMethyl Celecoxib(457639-26-8)
• EPA Substance Registry System: 2,5-DiMethyl Celecoxib(457639-26-8)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 457639-26-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 457639-26-8 differently. You can refer to the following data:
1. A non-cyclooxygenase-2 inhibitor analog of Celecoxib (C251000). The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib.
2. 2,5-Dimethyl-celecoxib has been usedTo block the synthesis of prostaglandin E2 and to study effect of transforming growth factor-2 signaling towards cyclooxygenase-2 expression.In an in vitro study to analyze its pro-oxidative capacities in metastatic melanoma/ breast cancer cells.To study its interaction between silymarin on chemically induced osteoarthritis in rats.

Biochem/physiol Actions

Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.

Downstream Products

• 1383381-41-6 4-(bis-N,N’-4-isopropylidene cyclohex-1-enylmethyloxycarbonyl[5-(2,5-dimethylphenyl)-3-trifluoromethylpyrazol-1-yl]benzenesulfonamide) 

Relevant articles and documents

1,5-diarylpyrazole derivative, and synthetic method and application thereof

The invention relates to a 1,5-diaryl pyrazole derivative and antibacterial application thereof. On the basis of a celecoxib structure, structural modification is conducted on 1,5-diaryl to obtain the 1,5-diaryl pyrazole derivative; and after structural c