Chemical Property of 2,5-Dimethylcelecoxib
Chemical Property:
- Melting Point:>138°C (dec.)
- Boiling Point:516.7±60.0 °C(Predicted)
- PKA:9.67±0.10(Predicted)
- PSA：86.36000
- Density:1.40±0.1 g/cm3(Predicted)
- LogP:5.60340
- Storage Temp.:room temp
- Solubility.:DMSO: soluble20mg/mL, clear
- XLogP3:3.8
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:3
- Exact Mass:395.09153242
- Heavy Atom Count:27
- Complexity:614
- Purity/Quality:
-
98%,99%, *data from raw suppliers
2,5-Dimethyl Celecoxib *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:T
- Statements:
25
- Safety Statements:
45
- MSDS Files:
-
Useful:
- Canonical SMILES:CC1=CC(=C(C=C1)C)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F
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Uses
A non-cyclooxygenase-2 inhibitor analog of Celecoxib (C251000). The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib. 2,5-Dimethyl-celecoxib has been usedTo block the synthesis of prostaglandin E2 and to study effect of transforming growth factor-2 signaling towards cyclooxygenase-2 expression.In an in vitro study to analyze its pro-oxidative capacities in metastatic melanoma/ breast cancer cells.To study its interaction between silymarin on chemically induced osteoarthritis in rats.
