457641-35-9 Usage
Uses
Used in Pharmaceutical Applications:
[(6-phenylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid is used as a lead compound for the development of new pharmaceuticals targeting a range of diseases. Its potential applications include anti-cancer, anti-inflammatory, and anti-viral properties due to the biological activities associated with thieno[2,3-d]pyrimidine derivatives.
Used in Antifungal and Antibacterial Applications:
In the field of infectious diseases, [(6-phenylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid is used as a potential agent for antifungal and antibacterial treatments. The thioacetic acid moiety in its structure has been studied for its effectiveness against various pathogens, making it a valuable compound for further research and development in this area.
Used in Drug Discovery and Development:
[(6-phenylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid is utilized as a candidate for drug discovery and development due to its unique chemical structure and properties. Its potential in various therapeutic areas, such as cancer, inflammation, and infectious diseases, makes it an attractive compound for further investigation and optimization to develop effective pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 457641-35-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,7,6,4 and 1 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 457641-35:
(8*4)+(7*5)+(6*7)+(5*6)+(4*4)+(3*1)+(2*3)+(1*5)=169
169 % 10 = 9
So 457641-35-9 is a valid CAS Registry Number.
457641-35-9Relevant academic research and scientific papers
Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin- 4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2
Golub, Andriy G.,Bdzhola, Volodymyr G.,Briukhovetska, Nadiia V.,Balanda, Anatoliy O.,Kukharenko, Olexander P.,Kotey, Igor M.,Ostrynska, Olga V.,Yarmoluk, Sergiy M.
, p. 870 - 876 (2011/04/22)
A novel series of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids has been synthesized and tested in vitro towards human protein kinase CK2. It was revealed that the most active compounds inhibiting CK2 are 3-{[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid and 3-{[5-(4-ethoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid (IC 50 values are 0.1 μM and 0.125 μM, respectively). Structure-activity relationships of 28 tested thienopyrimidine derivatives have been studied and binding mode of this chemical class has been predicted. Evaluation of the inhibitors on seven protein kinases revealed considerable selectivity towards CK2.
