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458532-84-8

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  • Featured products 2-chloro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

    Cas No: 458532-84-8

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458532-84-8 Usage

General Description

2-Chloropyridine-4-boronic acid pinacol ester, also known as 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, is a chemical compound with potential applications in organic synthesis and pharmaceutical research. It is a boronic acid ester derivative of 2-chloropyridine, which makes it a useful building block for the synthesis of various biologically active compounds and pharmaceuticals. Boronic acid pinacol esters have been widely utilized as versatile reagents in Suzuki-Miyaura cross-coupling reactions, allowing for the formation of carbon-carbon bonds and the synthesis of complex organic molecules. 2-Chloropyridine-4-boronic acid pinacol ester is characterized by its stability and ease of handling, making it a valuable tool for chemical synthesis and drug discovery efforts.

Check Digit Verification of cas no

The CAS Registry Mumber 458532-84-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,8,5,3 and 2 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 458532-84:
(8*4)+(7*5)+(6*8)+(5*5)+(4*3)+(3*2)+(2*8)+(1*4)=178
178 % 10 = 8
So 458532-84-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H15BClNO2/c1-10(2)11(3,4)16-12(15-10)8-5-6-14-9(13)7-8/h5-7H,1-4H3

458532-84-8 Well-known Company Product Price

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  • Alfa Aesar

  • (H50070)  2-Chloropyridine-4-boronic acid pinacol ester, 98%   

  • 458532-84-8

  • 1g

  • 1617.0CNY

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  • Alfa Aesar

  • (H50070)  2-Chloropyridine-4-boronic acid pinacol ester, 98%   

  • 458532-84-8

  • 5g

  • 7291.0CNY

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  • Aldrich

  • (ADE000250)  2-Chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine  AldrichCPR

  • 458532-84-8

  • ADE000250-1G

  • 4,512.69CNY

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458532-84-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloropyridine-4-boronic acid pinacol ester

1.2 Other means of identification

Product number -
Other names 2-Chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:458532-84-8 SDS

458532-84-8Downstream Products

458532-84-8Relevant articles and documents

para-Selective C?H Borylation of (Hetero)Arenes by Cooperative Iridium/Aluminum Catalysis

Yang, Lichen,Semba, Kazuhiko,Nakao, Yoshiaki

supporting information, p. 4853 - 4857 (2017/04/11)

para-Selective C?H borylation of benzamides and pyridines has been achieved by cooperative iridium/aluminum catalysis. A combination of iridium catalysts commonly employed for arene C?H borylation and bulky aluminum-based Lewis acid catalysts provides an unprecedented strategy for controlling the regioselectivity of C?H borylation to give variously substituted (hetero)arylboronates, which are versatile synthetic intermediates for complex multi-substituted aromatic compounds.

4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

Lahm, George P.,Cordova, Daniel,Barry, James D.,Pahutski, Thomas F.,Smith, Ben K.,Long, Jeffrey K.,Benner, Eric A.,Holyoke, Caleb W.,Joraski, Kathleen,Xu, Ming,Schroeder, Mark E.,Wagerle, Ty,Mahaffey, Michael J.,Smith, Rejane M.,Tong, My-Hahn

, p. 3001 - 3006 (2013/06/26)

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.

Synthesis of biaryls through a one-pot tandem borylation/Suzuki-Miyaura cross-coupling reaction catalyzed by a palladacycle

Wang, Lianhui,Cui, Xiuling,Li, Jingya,Wu, Yusheng,Zhu, Zhiwu,Wu, Yangjie

experimental part, p. 595 - 603 (2012/03/09)

The tricyclohexylphosphane adduct of cyclopalladated ferrocenylimine I exhibited high catalytic activity in the one-pot borylation/Suzuki-Miyaura coupling (BSC) reaction with low catalyst loading (2 mol-%). Various biaryls were obtained in good to excellent yields for 37 examples. This process was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups and did not require an excess amount of phosphane ligand and the addition of the palladium catalyst in the second step. Cyclopalladated ferrocenylimine I exhibited high catalytic activity in the borylation/Suzuki- Miyaura coupling (BSC) reaction with low catalyst loading. Various unsymmetrical biaryls were obtained ingood to excellent yields in one pot. This protocol was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups without adding catalyst in the second step. Copyright

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