2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Base Information

Chemical Name:2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No.:458532-84-8
Molecular Formula:C11H15BClNO2
Molecular Weight:239.51
Hs Code.:2934999090
European Community (EC) Number:640-537-3
DSSTox Substance ID:DTXSID30408358
Nikkaji Number:J1.748.339K
Wikidata:Q72458418
Mol file:458532-84-8.mol

Synonyms:458532-84-8;2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-Chloropyridine-4-boronic acid pinacol ester;2-Chloropyridine-4-boronic acid, pinacol ester;2-Chloro-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-pyridine;2-Chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine;Pyridine, 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;SCHEMBL394155;(2-CHLOROPYRIDIN-4-YL)BORONIC ACID PINACOL ESTER;2-chloro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;DTXSID30408358;UUEQDBHKMOFLDP-UHFFFAOYSA-N;BCP23069;AKOS015851291;AB17421;CS-W000937;DS-13045;A7189;AM20051200;C3529;FT-0677405;2-CHLOROPYRIDINE-4-BORONIC ACID PINACOL;EN300-212542;Q-103362;6-CHLOROPYRIDINE-4-BORONIC ACID PINACOL ESTER;2-chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine;2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine;2-Chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine, AldrichCPR;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen 2-chloropyridin-4-ylboronate;2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Suppliers and Price of 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloropyridine-4-boronicacid,pinacolester
250mg
$ 55.00

TRC
2-Chloropyridine-4-boronicacid,pinacolester
1g
$ 75.00

TCI Chemical
2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
5G
$ 275.00

TCI Chemical
2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
1G
$ 81.00

SynQuest Laboratories
2-Chloropyridine-4-boronic acid, pinacol ester
25 g
$ 628.00

SynQuest Laboratories
2-Chloropyridine-4-boronic acid, pinacol ester
5 g
$ 183.00

SynQuest Laboratories
2-Chloropyridine-4-boronic acid, pinacol ester
10 g
$ 314.00

Sigma-Aldrich
2-Chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine Aldrich
1g
$ 388.00

Matrix Scientific
2-Chloro-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-pyridine
1g
$ 132.00

Matrix Scientific
2-Chloro-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-pyridine
5g
$ 397.00

Total 72 raw suppliers

Chemical Property of 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Chemical Property:

Vapor Pressure:0.000196mmHg at 25°C
Melting Point:64.7-64.8 °C
Refractive Index:1.505
Boiling Point:338.2 °C at 760 mmHg
PKA:-0.58±0.10(Predicted)
Flash Point:158.3 °C
PSA：31.35000
Density:1.14 g/cm³
LogP:2.03420
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:239.0884366
Heavy Atom Count:16
Complexity:257

Purity/Quality:

≥99% ^*data from raw suppliers

2-Chloropyridine-4-boronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,T
Statements: 25-36
Safety Statements: 26-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:B1(OC(C(O1)(C)C)(C)C)C2=CC(=NC=C2)Cl

Technology Process of 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

There total 7 articles about 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 109-09-1
2-chloropyridine

: 73183-34-3
bis(pinacol)diborane

: 458532-84-8
2-chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine

Guidance literature:: bis(pinacol)diborane; With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In hexane; at 60 ℃; for 0.5h; Inert atmosphere; Glovebox; Sealed tube;

2-chloropyridine; With bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum; In hexane; at 20 ℃; for 6h; Sealed tube;
DOI:10.1002/anie.201701238

Reference yield: 60.0%

: 73583-37-6
2-chloro-4-bromopyridine

: 76-09-5
2,3-dimethyl-2,3-butane diol

: 458532-84-8
2-chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine

Guidance literature:: 2-chloro-4-bromopyridine; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; at -60 ℃; for 0.5h;

With Triisopropyl borate; In diethyl ether; at -70 - 10 ℃; for 2.5h;

2,3-dimethyl-2,3-butane diol; With acetic acid; In diethyl ether; for 4h;
DOI:10.1016/S0040-4020(02)00416-7

Reference yield:

: 109-09-1
2-chloropyridine

: 73183-34-3
bis(pinacol)diborane

: 444120-94-9
2-chloro-5-(4,4, 5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 458532-84-8
2-chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine

Guidance literature:: With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tert-butyl methyl ether; at 20 ℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;
DOI:10.1039/c4ob01565g