458549-94-5Relevant academic research and scientific papers
Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1
Folkes, Adrian,Brown,Canne, Lynne E.,Chan, Jocelyn,Engelhardt, Erin,Epshteyn, Sergey,Faint, Richard,Golec, Julian,Hanel, Art,Kearney, Patrick,Leahy, James W.,Mac, Morrison,Matthews, David,Prisbylla, Michael P.,Sanderson, Jason,Simon, Reyna J.,Tesfai, Zerom,Vicker, Nigel,Wang, Shouming,Webb, Robert R.,Charlton, Peter
, p. 1063 - 1066 (2007/10/03)
We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These studies resulted in the identification of several compounds which showed excellent potency against PAI-1. The design, synthesis and SAR of these compounds are described.
