458550-48-6

Usage

Uses

Used in Pharmaceutical Research:
N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine is used as a building block in the development of pharmaceutical drugs, specifically for the treatment of diseases such as cancer and inflammation. Its unique chemical structure and potential biological activities make it a valuable component in the creation of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine serves as a key intermediate for the synthesis of various organic compounds. Its reactivity and functional groups allow for the formation of diverse chemical entities, contributing to the advancement of organic chemistry.
It is crucial to handle and use N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine with care, adhering to relevant safety guidelines due to its chemical properties and potential biological activities.

InChI:InChI=1/C14H12N2O/c1-17-14-7-5-12(6-8-14)16-13-4-2-3-11(9-13)10-15/h2-9,16H,1H3

Upstream product

• 623-12-1 4-chloromethoxybenzene 
• 2237-30-1 m-cyanoaniline 
• 5720-07-0 4-methoxyphenylboronic acid 
• 619-24-9 3-nitrobenzonitrile 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Relevant academic research and scientific papers

Visible-Light- And PPh3-Mediated Direct C-N Coupling of Nitroarenes and Boronic Acids at Ambient Temperature

We present here a metal-free, visible-light- and triphenylphosphine-mediated intermolecular, reductive amination between nitroarenes and boronic acids at ambient temperature without any photocatalyst. Mechanistically, a slow reduction of nitroarenes to a nitroso and, finally, a nitrene intermediate occurs that leads to the amination product with concomitant 1,2-aryl/-alkyl migration from a boronate complex. A wide range of nitroarenes underwent C-N coupling with aryl-/alkylboronic acids providing high yields.

HISTONE DEMETHYLASE INHIBITORS

The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

Water-mediated catalyst preactivation: An efficient protocol for C-N cross-coupling reactions

(Figure Presented) A protocol for forming a highly active Pd(O) catalyst from Pd(OAc)2, water, and biaryldialkylphosphine ligands has been developed. This protocol generates a catalyst system, which exhibits excellent reactivity and efficiency in the coupling of a variety of amides and anilines with aryl chlorides.

A new general preparation of polyfunctional diarylamines by the addition of functionalized arylmagnesium compounds to nitroarenes

The addition of functionalized arylmagnesium halides to nitroarenes in THF (-20 °C, 2 h) provides, after reductive workup (FeCl2, NaBH4), various polyfunctional diarylamines in 63-86% yield. Heterocyclic arylated amines can be prepar