458564-00-6

Upstream product

• 120-72-9 indole 
• 340757-34-8 ethyl (3S)-2-ethoxycarbonyl-3-(3-indolyl)-3-phenyl-propanoate 
• 5292-53-5 diethyl benzalmalonate 
• 74-88-4 methyl iodide 
• 458563-98-9 (S)-ethyl 3-(1H-indol-3-yl)-3-phenylpropanoate 

Downstream Products

• 405873-09-8 (R)-3-(1-methyl-1H-indol-3-yl)-3-phenyl-propanal 

Relevant academic research and scientific papers

Controllable Enantioselective Friedel-Crafts Reaction between Indoles and Alkylidene Malonates Catalyzed by Pseudo-C3-Symmetric Trisoxazoline Copper(II) Complexes

Pseudo-C3-symmetric trisoxazoline copper(II) complexes prove to be excellent catalysts in the Friedel-Crafts alkylation of indoles with alkylidene malonates. The absolute stereochemistry of this reaction is shown to be dependent on the solvent.

Sidearm effect: Improvement of the enantiomeric excess in the asymmetric Michael addition of indoles to alkylidene malonates

A pseudo-C3-trisoxazoline was designed and synthesized. The improvement of the traditional bisoxazoline into a novel trisoxazoline by a sidearm approach resulted in highly catalytic enantioselective Michael addition of indoles to alkylidene mal