459196-49-7Relevant academic research and scientific papers
2,4-Disubstituted pyrimidines: A novel class of KDR kinase inhibitors
Manley, Peter J.,Balitza, Adrienne E.,Bilodeau, Mark T.,Coll, Kathleen E.,Hartman, George D.,McFall, Rosemary C.,Rickert, Keith W.,Rodman, Leonard D.,Thomas, Kenneth A.
, p. 1673 - 1677 (2003)
2,4-Disubstituted pyrimidines were synthesized as a novel class of KDR kinase inhibitors. Evaluation of the SAR of the screening lead compound 1 (KDR IC50=105 nM, Cell IC50=8% inhibition at 500 nM) led to the potent 3,5-dimethylaniline derivative 2d (KDR IC50=6 nM, cell IC50=19 nM).
