459422-06-1

Upstream product

• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 3132-99-8 m-bromobenzoic aldehyde 
• 126-81-8 dimedone 
• 61-82-5 3-amino-1,2,4-triazole 

Relevant academic research and scientific papers

Design and synthesis of nickel tetra‐2,3‐pyridiniumporphyrazinato trinitromethanide as an influential catalyst and its application in the synthesis of 1,2,4-triazolo based compounds

The facile and benign syntheses of [1,2,4]triazolo[5,1-b]quinazolines and [1,2,4]triazolo[1,5-b]pyrimidines were studied using novel nickel tetra‐2,3‐pyridiniumporphyrazinato trinitromethanide [Ni(TPPAH)][C(NO2)3]4 as an e

Heterogeneous AlPO4(SO3H) nanosheets: novel catalyst for the multi-component synthesis of quinazolinones and highly functionalized piperidines

Abstract: Nanosheets AlPO4(SO3H) as a highly active solid acid catalyst were prepared and characterized. The morphology of obtained catalyst exhibited nanosheets with?～?25–35?nm thickness. The heterogeneous nanocatalyst was characterized by FT-IR, EDX, and FE-SEM analysis. The nanosulfonated-AlPO4 were found useful for cyclization synthesis of highly functionalized piperidines and quinazolinones derivatives in good to excellent yields. Notable features include easy and quick isolation of products, ease of handling of the catalyst at low cost, no need to purify with column chromatography, and mild reaction conditions. In addition, according to the literature, another significant feature of our method for quinazolinone synthesis is that structurally diverse molecules were synthesized. Finally, the newly developed catalytic systems avoid the use of toxic metal catalysts and were reused up to 5 times without a noticeable their catalytic activity.

An efficient, one-pot three components synthesis of [1,2,4] triazoloquinazolinone derivatives using anthranilic acid as green catalyst

A simple, efficient and convenient approach has been reported for the synthesis of quinazolines by the condensation of 3-amino, 1,2,4-triazole with dimedone and different aromatic aldehydes in the presence of anthranilic acid as a catalyst through a one-p