459425-75-3

Upstream product

• 90813-54-0 2',5'-bis-O-tert-butyldimethylsilyl-3'-ketouridine 
• 3989-45-5 N-benzylmethanesulfonamide 
• 459425-74-2 N-benzyl-C-[4-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-3-yl]-methanesulfonamide 

Downstream Products

• 459425-76-4 2'-(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine 
• 808148-15-4 2'-(O-tert-butyldimethylsilyl)-3'-α-(N-benzyl methylenesulfonamido)-3'-deoxy-uridine 

Relevant academic research and scientific papers

Multiple routes for the synthesis of N-acyl sulfonamide-bridged nucleosides

Methods are described for the synthesis of uridine nucleoside derivatives containing an α-3″-methylenesulfonamide functionality. Several monomers possessing this functionality in both ribo- and deoxyribo-forms are detailed. Use of these monomers to construct the first N-acylsulfonamide-bridged dinucleoside is also described.