45951-62-0Relevant academic research and scientific papers
Reactions of the Monomeric Metaphosphate Anion Generated from Different Sources
Ramirez, Fausto,Marecek, James F.,Yemul, Shrishailam S.
, p. 1345 - 1349 (2007/10/02)
The reactions of 0.2 M acetonitrile solutions of 2,4-dinitrophenyl dihydrogen phosphate and erythro-1-phenyl-1,2-dibromopropylphosphonic acid containing 2 molar equiv of diisopropylethylamine have been studied at 25 deg C by means of 31P NMR spectrometry
Monomeric Metaphosphate Anion: Reaction with Carbonyl Groups
Satterthwait, Arnold C.,Westheimer, F. H.
, p. 1177 - 1180 (2007/10/02)
The elusive monomeric metaphosphate anion is generated rapidly at room temperature by the fragmentation of threo- or erythro- (1,2-dibromo-1-phenylpropyl)phosphonate in the presence of a hindered base; it reacts at the carbonyl groups of acetophenone and
Mechanism of Hydrolysis of Phosphorylethanolamine Diesters. Intramolecular Nucleophilic Amine Participation
Lazarus, Robert A.,Benkovic, Patricia A.,Benkovic, Stephen J.
, p. 373 - 379 (2007/10/02)
Intramolecular displacement reactions at phosphorus have been examined in a series of N-alkyl-O-arylphosphorylethanolamines in water at 35 deg C.The examination of the pH-rate profiles and the direct observation by 31P n.m.r. of the reaction products implicate a nucleophilic role for the amine.A rate enhancement of 1E6-1E7 is observed.Structure-reactivity correlations derived by changing the pKa of the amine and leaving group yield values for βnuc 0.7 and βlg -1.25 and support an uncoupled concerted mechanism.A discussion of the mechanisms of nucleophilic reactions involving amines and oxyanions with inter- and intra-molecular phosphate di- and tri-esters is presented.
