459818-48-5

Usage

Also known as

Zardaverine

Type of compound

Phosphodiesterase inhibitor

Potential use

Treatment of asthma and chronic obstructive pulmonary disease (COPD)

Mechanism of action

Inhibits the enzyme phosphodiesterase, which is involved in the breakdown of cyclic AMP, leading to relaxation of smooth muscle and improved lung function

Other potential applications

Treatment of cardiovascular diseases and cancer

Upstream product

• 634152-66-2 (RS)-3-benzylsulfanyl-2-methyl-2-ureido-propionic acid 
• 84888-71-1 5-benzylsulfanylmethyl-5-methyl-imidazolidine-2,4-dione 

Downstream Products

• 1227870-44-1 (S)-5-methyl-5-phenylmethanesulfonylmethyl-imidazolidine-2,4-dione 

Relevant academic research and scientific papers

NOVEL CRYSTAL MODIFICATIONS

Novel crystal modifications of (5S)-5-[4-(5-chloro-pyridin-2-yloxy)-piperidine-1-sulfonylmethyl]-5-methyl-imidazolidine-2,4-dione are disclosed together with processes for preparing such modifications, pharmaceutical compositions comprising such a modification, and the use of such a modification in therapy.

1-SULPHONYL PIPERIDINE DERIVATIVES

Piperidine derivatives of formula (1) that are useful in the inhibition of metalloproteinases, in particular TNF-α Converting Enzyme (TACE) and thus in the treatment of autoimmune disease, allergic/atopic diseases, transplant rejection, graft versus host disease, cardiovascular disease, reperfusion injury and malignancy.

IMIDAZOLIDINEDIONE-DERIVATIVES AND THEIR USE AS METALLOPROTEINASE INHIBITORS

The invention provides compounds of formula in which R1, G1 and G2 have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.