459870-98-5

Basic information

• Product Name: (3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone
• Synonyms: (3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone
• CAS NO: 459870-98-5
• Molecular Weight: 350.53
• Mol File: 459870-98-5.mol

Chemical Properties

• CAS DataBase Reference: (3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone(459870-98-5)
• EPA Substance Registry System: (3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone(459870-98-5)

Safety Data

• Hazardous Substances Data: 459870-98-5(Hazardous Substances Data)

Upstream product

• 459870-95-2 3-(tert-butyl-dimethyl-silanyloxy)-pentanedial 
• 139656-31-8 tert-butyl(hepta-1,6-dien-4-yloxy)dimethylsilane 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 1517-69-7 (R)-1-phenylethanol 
• 2883-45-6 1, 6-heptadien-4-ol 
• 459870-97-4 4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2,6-diol 

Relevant articles and documents

Diastereoselective and enantioselective preparation of nor-mevaldic acid surrogates through desymmetrisation methodology. Enantioselective synthesis of (+) and (-) nor-mevalonic lactones

Solvent-free desymmetrisation of a meso-dialdehyde with chiral alcohols, led to preparation of 4-silyloxy-6-alkyloxytetrahydro-2H-pyran-2-one derivatives with a 96% de. This methodology, which yields the corresponding methyl nor-mevaldates with 99% ee, ha

nor-Mevaldic acid surrogates as selective antifungal agent leads against Botrytis cinerea. Enantioselective preparation of 4-hydroxy-6-(1-phenylethoxy)tetrahydro-2H-pyran-2-one

Abstract Solvent-free desymmetrisation of meso-dialdehyde 1 with chiral 1-phenylethan-1-ol, led to preparation of 4-silyloxy-6-alkyloxytetrahydro-2H-pyran-2-one (+)-3a with a 96:4 dr Deprotected lactone (+)-19a and the related racemic lactones 16a-18a pre

Desymmetrisation of dialdehydes: (+)-(S) and (-)-(R) nor-methyl mevaldate as versatile synthetic intermediates

Desymmetrisation of 3-(t-butyldimethylsilyloxy)pentanedial 2 may be carried out by monoacetalisation with (R)- or (S)-2-phenylethanol. The products may be elaborated to nor-methyl mevaldate derivatives.