459871-05-7Relevant academic research and scientific papers
Desymmetrisation of dialdehydes: (+)-(S) and (-)-(R) nor-methyl mevaldate as versatile synthetic intermediates
Buckley, Shirley L.J.,Drew, Michael G.B.,Harwood, Laurence M.,Macías-Sánchez, Antonio J.
, p. 3593 - 3596 (2002)
Desymmetrisation of 3-(t-butyldimethylsilyloxy)pentanedial 2 may be carried out by monoacetalisation with (R)- or (S)-2-phenylethanol. The products may be elaborated to nor-methyl mevaldate derivatives.
nor-Mevaldic acid surrogates as selective antifungal agent leads against Botrytis cinerea. Enantioselective preparation of 4-hydroxy-6-(1-phenylethoxy)tetrahydro-2H-pyran-2-one
Botubol-Ares, José Manuel,Durán-Pe?a, María Jesús,Hernández-Galán, Rosario,Collado, Isidro G.,Harwood, Laurence M.,Macías-Sánchez, Antonio J.
, p. 3379 - 3387 (2015/08/03)
Abstract Solvent-free desymmetrisation of meso-dialdehyde 1 with chiral 1-phenylethan-1-ol, led to preparation of 4-silyloxy-6-alkyloxytetrahydro-2H-pyran-2-one (+)-3a with a 96:4 dr Deprotected lactone (+)-19a and the related racemic lactones 16a-18a pre
