459871-14-8Relevant articles and documents
L-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of L-histidine and L-tryptophan
Hall, Colton,Wolfe, Hannah,Wells, Alyssa,Chien, Huan-Chieh,Colas, Claire,Schlessinger,Giacomini, Kathleen M.,Thomas, Allen A.
, p. 2254 - 2258 (2019)
A series of 1,2,3-triazole analogs of the amino acids L-histidine and L-tryptophan were modeled, synthesized and tested for L-type amino acid transporter 1 (LAT1; SLC7A5) activity to guide the design of amino acid-drug conjugates (prodrugs). These triazol
Total synthesis of deamido bleomycin A2, the major catabolite of the antitumor agent bleomycin
Zou, Ying,Fahmi, Nour Eddine,Vialas, Corine,Miller, Guy M.,Hecht, Sidney M.
, p. 9476 - 9488 (2007/10/03)
Metabolic inactivation of the antitumor antibiotic bleomycin is believed to be mediated exclusively via the action of bleomycin hydrolase, a cysteine proteinase that is widely distributed in nature. While the spectrum of antitumor activity exhibited by th