460-07-1

Basic information

• Product Name: N-ACETYLETHYLENEIMINE
• Synonyms: 1-acetyl-aziridin;1-acetylaziridine;acetylethyleneimine;N-ACETYLETHYLENEIMINE;AEI;1-aziridin-1-ylethanone;N,N-ethylideneacetamide;N-Acetylethylenimine
• CAS NO: 460-07-1
• Molecular Formula: C₄H₇NO
• Molecular Weight: 85.1
• EINECS: 207-301-8
• Product Categories: Miscellaneous Reagents;Heterocycles
• Mol File: 460-07-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 161 °C
• Boiling Point: 44-45°C
• Flash Point: 76.2°C
• Appearance: /
• Density: 1.0408 (rough estimate)
• Vapor Pressure: 1.22mmHg at 25°C
• Refractive Index: 1.4340 (estimate)
• Storage Temp.: -20?C Freezer
• PKA: -2.36±0.20(Predicted)
• Stability: Store in Freezer
• CAS DataBase Reference: N-ACETYLETHYLENEIMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ACETYLETHYLENEIMINE(460-07-1)
• EPA Substance Registry System: N-ACETYLETHYLENEIMINE(460-07-1)

Safety Data

• Hazardous Substances Data: 460-07-1(Hazardous Substances Data)

Usage

Chemical Properties

Clear Colourless Liquid

Uses

N-AcetylethyleniMine is suitable for the inactivation of foot-and-mouth disease virus (FMDV) and poliovirus for the preparation of virus vaccines. N-AcetylethyleniMine inactivation of FMDV and poliovirus is demonstrated without impa iring the biological properties of several proteins under conditions which render the viruses inocuous. AEI-inactivated FMDV is adsorbed and uncoated by BHK cells as efficiently as untreated virus, i ndicating that any viral proteins involved in the attachment and uncoating process are unaffected by imine inactivation.

Safety Profile

Poison by intraperitoneal route. Questionable carcinogen with experimental tumorigenic and neoplastigenic data. When heated to decomposition it emits toxic fumes of NOx,.

InChI:InChI=1/C4H7NO/c1-4(6)5-2-3-5/h2-3H2,1H3

Upstream product

• 151-56-4 ethyleneimine 
• 75-36-5 acetyl chloride 
• 463-51-4 Ketene 

Downstream Products

• 1190-73-4 2-(acetylamino)ethanethiol 
• 92349-49-0 bis(2-acetylaminoethyl) sulfide 
• 126377-36-4 N-<2-<<2-(1H-imidazol-4-yl)ethyl>(phenylmethyl)amino>ethyl>acetamide 
• 69622-45-3 o-(acetylmethyl)phenyl isocyanide 

Relevant articles and documents

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CARBOCYCLIC COMPOUNDS

Novel carbocyclic compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

CARBOCYCLIC COMPOUNDS

Novel carbocyclic compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.