178181-52-7Relevant academic research and scientific papers
Generating Monofluoro-Substituted Amines and Amino Acids by the Interaction of Inexpensive KF and Sulfamidates
Liang, Lu-Lu,Niu, Liang-Feng,Xu, Zhi-Hong,Yang, Lijun,Yao, Chuan,Zeng, Jun-Liang,Zou, Yu-Lu
, (2022/02/19)
The regioselective ring-opening of 1,2- and 1,3-sulfamidates with fluorine anion is reported. Direct construction of monofluoro-substituted amines and amino acid derivatives using inexpensive and easily available potassium fluoride (KF). The monofluorinat
CYCLIC IMINOPYRIMIDINE DERIVATIVES AS KINASE INHIBITORS
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Paragraph 0233, (2019/04/16)
Provided are cyclic iminopyridimdine compounds and their bicyclic derivatives, pharmaceutical compositions comprising such compounds, and methods of using such compounds or compositions, such as methods of treating a proliferation disorder, such as a cancer or a tumor, or in some embodiments disease or disorders related to the dysregulation of kinase such as, but not limited to B-Raf V600E kinase.
ARYL, HETEROARY, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS
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Page/Page column 650, (2018/09/21)
Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.
HIV Integrase Inhibitors
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Page/Page column 49, (2009/10/17)
The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
C-terminal 18F-fluoroethylamidation exemplified on [Gly-OH9] oxytocin
Jelinski,Hamacher,Coenen
, p. 217 - 229 (2007/10/03)
The no-carrier-added (n.c.a.) 18F-fluoroethylamidation of the acid function of the protected nonapeptide Boc-Cys-Tyr(tBu)-Ile-Gln(Mtt)-Asn(Mtt)-Cys-Pro-Leu-Gly-OH forming the labelled peptide hormone derivative [Gly-(2-[18F]fluoroeth
Synthesis of N-(2-[18F]fluoroethyl)-N'-methylthiourea: A hydrogen peroxide scavenger
Gilissen,Bormans,De Groot,Verbruggen
, p. 491 - 502 (2007/10/03)
N-(2-[18F]fluoroethyl)-N'-methylthiourea ([18F]FEMTU), a fluorine- 18 labelled derivative of the hydrogen peroxide scavenger dimethylthiourea (DMTU), has been synthesized by reaction of 2-[18F]fluoroethylamine with methyli
