460-75-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(Trifluoromethyl)acetamide is used as a building block for the synthesis of various pharmaceutical compounds. Its unique trifluoromethyl group imparts specific properties to the final product, enhancing their therapeutic effects and pharmacokinetics.
Used in Agrochemical Industry:
2-(Trifluoromethyl)acetamide is used as a key intermediate in the production of agrochemicals, such as pesticides and herbicides. The incorporation of the trifluoromethyl group can improve the efficacy and selectivity of these compounds, leading to more effective crop protection.
Used in Production of Fluorinated Compounds:
2-(Trifluoromethyl)acetamide is used as a precursor in the synthesis of fluorinated compounds, which have a wide range of applications in various industries, including materials science, electronics, and specialty chemicals.
Used as a Solvent:
2-(Trifluoromethyl)acetamide is used as a solvent in various chemical reactions due to its ability to dissolve a wide range of organic compounds and its compatibility with different reaction conditions.
Used as an Intermediate in Chemical Reactions:
2-(Trifluoromethyl)acetamide serves as an intermediate in the synthesis of other organic compounds, facilitating the formation of desired products through its high reactivity and stability.

Upstream product

• 41463-83-6 3,3,3-trifluoropropanoyl chloride 
• 433-26-1 1,1,1-trifluoro-3-diazo-2-oxopropane 

Downstream Products

• 753-90-2 trifluoroethylamine 
• 432-74-6 2,3-dibromo-3,3-difluoro-propionic acid bromoamide 
• 460-39-9 3,3,3-trifluoropropylamine 

Relevant academic research and scientific papers

Method for producing 3, 3, 3 - [...] (by machine translation)

PROBLEM TO BE SOLVED: To provide a simple, efficient and inexpensive method capable of manufacturing a 3,3,3-trifluoro propionyl compound useful as a pharmaceutical and agricultural synthetic intermediate in an industrial scale.SOLUTION: There is provided a method of manufacturing a compound represented by the formula [1] by reacting a compound represented by the formula [2] with a polar compound after hydrolysis with using sulfuric acid. In the formula [1], X is Cl, OH, ORor NRR, Ris a Cto Calkyl group, a Cto Chalogenated alkyl group or phenyl group, Rand Rmay be same or different and are each independently a hydrogen, a Cto Calkyl group, a Cto Chalogenated alkyl group or phenyl group and each may together form a ring structure.

Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: Design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the α2-adrenoceptor

(±)-7-Aminosulfonyl-3-fluoromethyl-1,2,3,4-tetrahydroisoquinoline (7) is one of the most potent and selective inhibitors of phenylethanolamine N-methyltransferase (PNMT) reported to date, but a blood-brain barrier (BBB) model indicates that it cannot penetrate the BBB. To increase the lipophilicity of 7 by addition of a nonpolar substituent to the sulfonamide nitrogen, a small library of (±)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4- tetrahydroisoquinolines was synthesized and evaluated as inhibitors of PNMT and for affinity at the α2-adrenoceptor. In addition, this library probed the PNMT active site surrounding the sulfonamide nitrogen of 7. Bulky substituents on the sulfonamide nitrogen are disfavored at the PNMT active site more so than at the α2-adrenoceptor (thus reducing selectivity). On the other hand, alkyl chains on the sulfonamide nitrogen that contain an electron dense atom, such as a fluorine, are favored in the PNMT active site and possess little α2-adrenoceptor affinity, thereby conferring good selectivity (>500). Several members of the library (8, 14, 17, and 18) have excellent PNMT inhibitory potency and selectivity and are predicted, on the basis of their ClogP value (>0.5), to penetrate the BBB to a significant extent. Compounds 17 and 18 are the most potent and selective PNMT inhibitors reported to date.

Halogenoalkylcarbamic acid ester pesticides

Halogenoalkylcarbamic acid esters of the formula STR1 in which R, R1 and R2 independently of one another represent methyl which is optionally substituted by halogen, at least one of the methyl groups R, R1 and R2 being substituted by at least one halogen atom, R3, R4 and R5 are identical or different and individually represent hydrogen or optionally substituted alkyl and n represents 0 or 1, synergize the action of known arthropodicides.