46000-25-3

Upstream product

• 51812-96-5 4-mercaptoquinoline 
• 74-88-4 methyl iodide 
• 611-35-8 4-chloroquinoline 
• 5188-07-8 sodium thiomethoxide 
• 616-38-6 carbonic acid dimethyl ester 
• 611-36-9 quinolin-4-ol 
• 3964-04-3 4-bromoquinoline 
• 91-22-5 quinoline 
• 77-78-1 dimethyl sulfate 
• 14095-26-2 γ,γ'-diquinolinyl sulfide 

Downstream Products

• 83-54-5 1-methyl-4-quinolone 
• 17075-20-6 4-Methylsulfonyl-chinolin 
• 6291-51-6 1-methyl-1H-quinoline-4-thione 

Relevant academic research and scientific papers

Experimental and computational investigation of unsymmetrical cyanine dyes: Understanding torsionally responsive fluorogenic dyes

Unsymmetrical cyanine dyes are widely used in biomolecular detection due to their fluorogenic behavior, whereby fluorescence quantum yields can be very low in fluid solution but are significantly enhanced in conformationally restricted environments. Herei

Nickel-Catalyzed Cyanation of Aryl Thioethers

A nickel-catalyzed cyanation of aryl thioethers using Zn(CN)2 as a cyanide source has been developed to access functionalized aryl nitriles. The ligand dcype (1,2-bis(dicyclohexylphosphino)ethane) in combination with the base KOAc (potassium acetate) is essential for achieving this transformation efficiently. This reaction involves both a C-S bond activation and a C-C bond formation. The scalability, low catalyst and reagents loadings, and high functional group tolerance have enabled both late-stage derivatization and polymer recycling, demonstrating the reaction's utility across organic chemistry.

Palladium-Catalyzed Thiomethylation via a Three-Component Cross-Coupling Strategy

In this report, the combination of masked inorganic sulfur and dimethyl carbonate was designed to achieve thiomethylated cross coupling of aryl chlorides. Remarkably, this powerful strategy realized thiomethylation of nucleosides bearing unprotected ribose, chloride-containing pharmaceuticals with late-stage coupling, and herbicides possessing multiple heteroatoms and steric hindrance. Moreover, this protocol is practically amenable to multigram-scale synthesis with a lower catalysis loading and a higher yield.

Methyl aryl thioether compound, and synthetic method and applications thereof

The invention discloses a methyl aryl thioether compound represented by formula 2, and a synthetic method and applications thereof. According to the synthetic method, in a reaction solvent, an aryl halide or an aromatic halide, dimethyl carbonate, and potassium thioacetate are taken as reaction raw materials, reaction is carried out in the presence of metal palladium catalyst under the action of a ligand and an alkali so as to obtain the methyl aryl thioether compound. The reaction conditions of the synthetic method are mild; the raw materials are cheap and easily available; reaction operation is simple; yield is relatively high. The methyl aryl thioether compound can be used for providing skeleton structures for the synthesis of a plurality of natural products and medicines, and can be widely applied in industrialized large-scale production.

Efficient nucleophilic substitution reactions of quinolyl and isoquinolyl halides with nucleophiles under focused microwave irradiation

Nucleophilic substitution reactions of 2-chloroquinoline, 3-bromoquinoline and 4-bromoisoquinoline with thiolate, alkoxy ions and aniline were completed within several minutes under microwave irradiation. This method gives the desired products with yields up to 99% in a short reaction time, and is superior to the classical heating process.

SYNTHESIS OF ARYL THIOCYANATES FROM ARYL ALKYL SULPHIDES. CONVERSION OF UNACTIVATED ARYL HALIDES INTO ARYL THIOCYANATES

Aryl alkyl sulphides, easily obtained from aryl halides, can be selectively dealkylated in HMPA by treatment with sodium, sodium methanethiolate or sodium methoxide.The resulting solutions, containing the sodium arenethiolates, when treated with BrCN or ICN, afford the corresponding aryl thiocyanates in moderate to good yields.A by-product is obtained in several cases to whom the structure of ArSP(O)(NMe2)2 has been attributed.

SULFURATION OF AZINES. PART I. THIOQUINANTHRENE, STRUCTURE, SYNTHESIS AND CLEAVAGE REACTION OF 1,4-DITHIIN RING

It has been shown that thioquinanthrene has a structure of 1,4-dithiino(2,3-c:5,6-c')diquinoline.New methods of synthesis of thioquinanthrene are described and reactivity of the 4-quinolyl-sulfur bond in presence of sodium sulfide has been established.

A CONVENIENT SYNTHESIS OF AROMATIC THIOLS FROM UNACTIVATED ARYL HALIDES

Aromatic thiols are obtained in good yields from unactivated aryl halides and excess MeSNa in HMPA.