460053-17-2

Upstream product

• 460053-12-7 8-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-octan-4-one 
• 4039-83-2 3-(4-methoxybenzyloxy)propyne 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 460053-13-8 tert-butyl-{5-[3-(4-methoxy-benzyloxy)-propyl]-hex-5-enyloxy}-dimethyl-silane 

Downstream Products

• 460053-18-3 7-[3-(4-methoxy-benzyloxy)-propyl]-1-phenyl-oct-7-en-1-yn-3-ol 

Relevant academic research and scientific papers

Synthesis of oxaspiro[m.n] skeletons based on the Nicholas reaction

Treatment of alkyne-Co2(CO)6 complexes possessing a methylidene moiety as well as a terminal hydroxy functionality with SnCl4 at 0°C effected tandem ring-closure reactions resulting in the formation of 1-oxaspiro[4.4]nonane, 1-oxaspiro[4.5]decane, 6-oxaspiro[4.5]decane, and 1-oxaspiro[5.5]undecane frameworks in high yields.