4603-58-1Relevant academic research and scientific papers
Covalent alkylation of DNA with duocarmycin A. Identification of abasic site structure
Sugiyama,Hosoda,Saito,Asai,Saito
, p. 7197 - 7200 (1990)
Alkylation of d(CGTATACG) by antitumor antibiotic duocarmycin A was investigated. It was found that N3 of adenine6 (A6) attacks the cyclopropane subunit of duocarmycin A to produce covalently alkylated adduct 5. Upon heating (90 °C, 5 min) the adduct 5 decomposed to modified oligomer 1 with concomitant release of adenine adduct 2.
