Tetrahedron Letters p. 7197 - 7200 (1990)
Update date:2022-08-05
Topics:
Sugiyama
Hosoda
Saito
Asai
Saito
Alkylation of d(CGTATACG) by antitumor antibiotic duocarmycin A was investigated. It was found that N3 of adenine6 (A6) attacks the cyclopropane subunit of duocarmycin A to produce covalently alkylated adduct 5. Upon heating (90 °C, 5 min) the adduct 5 decomposed to modified oligomer 1 with concomitant release of adenine adduct 2.
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