460348-31-6Relevant articles and documents
Convergent stereospecific synthesis of C292 (or LL-Z1640-2), and hypothemycin. Part 1
Sellès, Patrice,Lett, Robert
, p. 4621 - 4625 (2007/10/03)
The stereospecific synthesis of the precursors required for the 14-membered ring formation either via an intramolecular Suzuki coupling or via an intermolecular Suzuki coupling followed by a macrolactonisation is herein reported. One-pot Suzuki couplings were here achieved with vinyldisiamylboranes which were generated in situ from the related chiral precursor. The present convergent approach of C292 (or LL-Z1640-2) and hypothemycin gives a flexible access to related macrolides.