460348-08-7

Upstream product

• 223511-04-4 tert-butyldimethylsilyl 2-((tert-butyldimethylsilyl)oxy)-4-methoxybenzoate 
• 460348-03-2 2-((tert-butyldimethylsilyl)oxy)-N,N-diethyl-4-methoxybenzamide 
• 58137-79-4 methyl 6-bromo-2,4-dimethoxybenzoate 

Downstream Products

• 460348-32-7 2-((E)-3-{(4S,5S)-5-[(Z)-(R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-hex-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-propenyl)-6-hydroxy-4-methoxy-benzoic acid methyl ester 
• 460348-10-1 2-bromo-6-hydroxy-4-methoxy-benzoic acid 
• 460348-31-6 2-Bromo-6-hydroxy-4-methoxy-benzoic acid (Z)-(S)-5-((4S,5S)-2,2-dimethyl-5-prop-2-ynyl-[1,3]dioxolan-4-yl)-5-(4-methoxy-benzyloxy)-1-methyl-pent-3-enyl ester 
• 460348-38-3 2-Hydroxy-6-((E)-3-{(4S,5S)-5-[(Z)-(R)-5-hydroxy-1-(4-methoxy-benzyloxy)-hex-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-propenyl)-4-methoxy-benzoic acid methyl ester 
• 1255639-78-1 C₄₈H₇₄O₇Si₃ 

Relevant academic research and scientific papers

Convergent stereospecific synthesis of C292 (or LL-Z1640-2), and hypothemycin. Part 1

The stereospecific synthesis of the precursors required for the 14-membered ring formation either via an intramolecular Suzuki coupling or via an intermolecular Suzuki coupling followed by a macrolactonisation is herein reported. One-pot Suzuki couplings were here achieved with vinyldisiamylboranes which were generated in situ from the related chiral precursor. The present convergent approach of C292 (or LL-Z1640-2) and hypothemycin gives a flexible access to related macrolides.

Total Synthesis of Paecilomycin B

Starting from the glucose-derived δ-lactone and the functionalized aryl bromide, the first total synthesis of naturally occurring paecilomycin B was achieved via functionalized aryl-β-C-glycoside synthesis using 2,4,6-triisopropylphenyllithium under Barbi