46041-69-4

Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-(PIPERIDIN-2-YL)PYRIDINE is used as a synthetic intermediate for the development of various drugs and active pharmaceutical ingredients (APIs), leveraging its unique structural properties to enhance the therapeutic efficacy of medications.
Used in Medicinal Chemistry:
(S)-2-(PIPERIDIN-2-YL)PYRIDINE is utilized as a building block in the synthesis of heterocyclic compounds, which are integral to the design of novel pharmaceutical agents with diverse biological activities.
Used in Organic Chemistry Reactions:
(S)-2-(PIPERIDIN-2-YL)PYRIDINE serves as a reagent in organic chemistry, contributing to the advancement of chemical processes and the synthesis of complex organic molecules for various applications, including drug development.

Upstream product

• 1061659-71-9 (S)-2-(1-benzyl-2-piperidinyl)pyridine 

Relevant academic research and scientific papers

Chiral ligand 2-(2′-piperidinyl)pyridine: synthesis, resolution and application in asymmetric diethylzinc addition to aldehydes

Chiral ligand 2-(2′-piperidinyl)pyridine 1 has been synthesized in good overall yield by sequential benzylation, hydrogenation and debenzylation of 2,2′-bipyridine. Its enantiomerically pure enantiomers have been obtained by resolution of 2-(1-benzyl-2-piperidinyl)pyridine 2 with d-tartaric acid (or l-tartaric acid) followed by debenzylation. The absolute configuration was determined by X-ray analysis of the (S)-2 d-tartrate. It was demonstrated that 1 can be used as an effective enantioselective catalyst in the addition of diethylzinc to aldehydes. Optically active secondary alcohols with up to 100% enantiomeric excess were obtained in high yields.