461-24-5

Usage

Appearance

Colorless liquid with a strong ether-like odor

Flammability

Flammable

Uses

Solvent in various chemical processes and reactions, extraction agent for separating organic compounds, reagent in the synthesis of pharmaceuticals and agrochemicals

Health hazards

Can cause irritation to the respiratory system and skin, prolonged exposure can lead to more serious health effects

Environmental hazards

Volatile organic compound that can contribute to air pollution if not properly controlled and managed.

InChI:InChI=1/C4H7F3O/c1-2-8-3-4(5,6)7/h2-3H2,1H3

Upstream product

• 64-17-5 ethanol 
• 133367-80-3 C₁₁H₁₂F₃N₃O₂ 
• 75-88-7 1,1,1-trifluoro-2-chloroethane 

Downstream Products

• 453-35-0 1,1,1-trifluoro-3-nitro-2-propanol 

Relevant academic research and scientific papers

Synthesis of trifluoroethyl ethers from 2,2,2-trifluoroethyl chloride (HCFC-133a) in high temperature aqueous medium

Treatment of 2,2,2-trifluoroethyl chloride (HCFC-133a) with alcohols (phenols) and aqueous KOH in autoclave at 240-280 C gives the corresponding 2,2,2-trifluoroethyl (2-chloro-1,1-difluoroethyl) ethers in good yields.

Triazene Drug Metabolites. Part 10. Metal-ion Catalysed Decomposition of Monoalkyltriazenes in Ethanol Solutions

The metal ions Fe(2+), Zn(2+) and Cu(2+) bring about the rapid decomposition of 1-aryl-3-alkyltriazenes to the corresponding anilines.For Fe(2+), a linear dependence of the pseudo-first-order rate constant, k0, on was observed, while for Zn(2+) and Cu(2+) plots of k0 versus were curved and indicative of complex formation.For Fe(2+), second-order rate constants k2Fe(2+) for substituted 1-aryl-3-methyltriazenes follow a Hammett relationship giving rise to a ρ value of -3.0.For Zn(2+) and Cu(2+), the data were analysed in terms of an equilibrium konstant, KM(2+), for the dissociation of a metal-ion-triazene complex and the first-order rate constant, for the collapse of this complex to products, k2M(2+).Hammett ρ values of 1.0 for both KZn(2+) and KCu(2+) are found, and the corresponding ρ values for k2Zn(2+) and k2Cu(2+) are -1.3 and -1.9.There is reasonable correlation between the Taft Eg parameter for the alkyl group and KCu(2+), giving a δ value of -1.6.The dependence of k2Cu(2+) on the alkyl group is not simple: k2Cu(2+) decreases in the order Pr > Et * PhCH2 ca. 4-MeOC6H4CH2 > CD3 ca.Me.The reactions catalysed by Cu(2+) are inhibited by added nucleophiles e.g.Br(1-) and N-methylimidazole. A mechanism is proposed in which the triazene complexes to the metal ion via the N(1) nitrogen atom of the E-cis conformer, then undergoes a fast proton transfer to form a complex involving the unconjugated tautomer which subsequently decomposes via unimolecular scission of the N(2)-N(3) bond to form an alkyldiazonium ion and an aniline-metal complex.The observed products then arise from rapid solvolysis of the metal-aniline complex and the alkyl diazonium ion.