461044-98-4

Basic information

• Product Name: Acetic acid (1R,2S)-2-benzyloxy-1-[(dibenzylamino)-methyl]-2-(diethoxy-phosphoryl)-ethyl ester
• CAS NO: 461044-98-4
• Molecular Weight: 539.609
• Mol File: 461044-98-4.mol

Chemical Properties

• CAS DataBase Reference: Acetic acid (1R,2S)-2-benzyloxy-1-[(dibenzylamino)-methyl]-2-(diethoxy-phosphoryl)-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid (1R,2S)-2-benzyloxy-1-[(dibenzylamino)-methyl]-2-(diethoxy-phosphoryl)-ethyl ester(461044-98-4)
• EPA Substance Registry System: Acetic acid (1R,2S)-2-benzyloxy-1-[(dibenzylamino)-methyl]-2-(diethoxy-phosphoryl)-ethyl ester(461044-98-4)

Safety Data

• Hazardous Substances Data: 461044-98-4(Hazardous Substances Data)

Upstream product

• 461044-94-0 Acetic acid (1S,2S)-2-benzyloxy-1-bromomethyl-2-(diethoxy-phosphoryl)-ethyl ester 
• 461044-90-6 ((1S,2R)-1-Benzyloxy-2,3-dihydroxy-propyl)-phosphonic acid diethyl ester 
• 461044-92-8 ((S)-Benzyloxy-(R)-oxiranyl-methyl)-phosphonic acid diethyl ester 
• 210040-44-1 diethyl (1S,2R)-2,3-O-cyclohexylidiene-1,2,3-trihydroxypropylphosphonate 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Synthesis of diethyl (1R,2R)- and (1S,2R)-3-acetamido-1,2-dihydroxypropylphosphonates

Diastereomeric diethyl (1R,2R)- and (1S,2R)-2,3-epoxy-1-benzyloxypropylphosphonates were obtained from the respective 2,3-O-cyclohexylidene-1-hydroxypropylphosphonates via the following sequence of reactions: benzylation, acetal hydrolysis and transformation of the terminal diol into the epoxide using the Sharpless protocol. These epoxides were regioselectively opened with dibenzylamine to afford the title compounds after acetylation and hydrogenolysis.