46118-02-9

Usage

Uses

Used in Cosmetic Industry:
4-(3-HYDROXY-PROPYL)-BENZENE-1,2-DIOL is used as an antioxidant and skin conditioning agent for its ability to protect the skin from oxidative stress and provide moisturization, leading to improved skin health and appearance.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 4-(3-HYDROXY-PROPYL)-BENZENE-1,2-DIOL is utilized for its potential health benefits, which include antioxidant and anti-inflammatory properties that may contribute to the treatment or management of various conditions.
Used in Hair Care Products:
4-(3-HYDROXY-PROPYL)-BENZENE-1,2-DIOL is used as a hair care ingredient to provide conditioning and protect hair from damage, helping to maintain hair health and improve its overall quality.
Used as a Stabilizer in Cosmetic Formulations:
4-(3-HYDROXY-PROPYL)-BENZENE-1,2-DIOL also serves as a stabilizer in cosmetic products, ensuring the longevity and efficacy of the formulation by preventing the degradation of other ingredients, thus maintaining the product's quality over time.

InChI:InChI=1/C9H12O3/c10-5-1-2-7-3-4-8(11)9(12)6-7/h3-4,6,10-12H,1-2,5H2

Upstream product

• 10210-17-0 3-(4-hydroxyphenyl)propan-1-ol 
• 3598-22-9 methyl 3-(3,4-dihydroxyphenyl)propionate 
• 2305-13-7 3-Guaiacylpropanol 
• 3843-74-1 Methyl caffeate 
• 3598-26-3 (E)-4-(3-hydroxyprop-1-en-1-yl)benzene-1,2-diol 
• 331-39-5 caffeic acid 
• 13620-82-1 4-allyl-1,2-phenylene diacetate 
• 108-24-7 acetic anhydride 
• 1126-61-0 4-allylpyrocatechol 
• 94-59-7 1-allyl-3,4-methylenedioxybenzene 
• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 1078-61-1 dihydrocaffeic acid 

Downstream Products

• 1035080-49-9 C₁₈H₂₀O₅ 
• 1035080-39-7 C₁₆H₁₅ClO₃ 
• 1035080-41-1 C₁₆H₁₅NO₅ 
• 1035080-51-3 C₁₉H₂₂O₆ 
• 1035080-35-3 C₁₆H₁₆O₃ 
• 1035080-37-5 C₁₇H₁₈O₄ 
• 1035080-45-5 C₁₇H₁₈O₅ 
• 1035080-47-7 C₁₈H₂₀O₅ 
• 1035080-53-5 C₁₈H₁₈O₅ 

Relevant academic research and scientific papers

Very long-chain phenylpropyl and phenylbutyl esters from Taxus baccata needle cuticular waxes

The cuticular wax of Taxus baccata L. needles was found to contain four different classes of long-chain esters that were identified by various chemical transformations with product assignment employing GC-MS. Homologous series of (1) 3-(4′-hydroxyphenyl)-propyl esters of C20-C36 fatty acids, (2) 4-(4′-hydroxyphenyl)-2-butyl esters of C18-C28 fatty acids, (3) 3-(3′,4′-dihydroxyphenyl)-propyl esters of C20-C32 fatty acids, and (4) 4-(3′,4′-dihydroxyphenyl)-2-butyl esters of C18-C28 fatty acids were identified. The four compound classes amounted to 0.1-3.6 μg/cm2 of needle surface area, corresponding to 0.2-7.6% of the wax mixture, respectively. While both phenylpropyl ester series had a maximum for the homolog containing tetracosanoic acid, in the phenylbutyl esters homologs containing eicosanoic and docosanoic acids predominated.

METHOD FOR THE DEACYLATION AND/OR DEALKYLATION OF COMPOUNDS

The present invention in general relates to a method for the deacylation and/or dealkylation (both O-dealkylation as well as C-dealkylation) of compounds, more specifically of aromatic compounds. The method is characterized by contacting the compound with an acid-containing aqueous reaction mixture using high temperature and high pressure conditions. The invention also provides a method for preparing a compound suitable for further deacylation using the method of the invention.

A biocompatible alkene hydrogenation merges organic synthesis with microbial metabolism

Organic chemists and metabolic engineers use orthogonal technologies to construct essential small molecules such as pharmaceuticals and commodity chemicals. While chemists have leveraged the unique capabilities of biological catalysts for small-molecule production, metabolic engineers have not likewise integrated reactions from organic synthesis with the metabolism of living organisms. Reported herein is a method for alkene hydrogenation which utilizes a palladium catalyst and hydrogen gas generated directly by a living microorganism. This biocompatible transformation, which requires both catalyst and microbe, and can be used on a preparative scale, represents a new strategy for chemical synthesis that combines organic chemistry and metabolic engineering. Reduction to practice: A hydrogenation reaction has been developed that employs hydrogen generated in situ by a microorganism and a biocompatible palladium catalyst to reduce alkenes on a synthetically useful scale. This type of transformation, which directly combines tools from organic chemistry with the metabolism of a living organism for small-molecule production, represents a new strategy for chemical synthesis.

Design, synthesis and biological evaluation of small molecular polyphenols as entry inhibitors against H5N1

To find novel compounds against H5N1, three series of known or novel small molecular polyphenols were synthesized and tested in vitro for anti-H5N1 activity. In addition, the preliminary structure-antiviral activity relationships were elaborated. The results showed that some small molecular polyphenols had better anti-H5N1 activity, and could serve as novel virus entry inhibitors against H 5N1, likely targeting to HA2 protein. Noticeably, compound 4a showed the strongest activity against H5N1 among these compounds, and the molecular modeling analysis also suggested that this compound might target to HA2 protein. Therefore, compound 4a is well qualified to serve as a lead compound or scaffold for the further development of H 5N1 entry inhibitor.

Synthesis and structure/antioxidant activity relationship of novel catecholic antioxidant structural analogues to hydroxytyrosol and its lipophilic esters

A large panel of novel catecholic antioxidants and their fatty acid or methyl carbonate esters has been synthesized in satisfactory to good yields through a 2-iodoxybenzoic acid (IBX)-mediated aromatic hydroxylation as the key step. The new catechols are

New catechol derivatives of safrole and their antiproliferative activity towards breast cancer cells

Catechols were synthesized from safrole. Nine derivatives were prepared and assessed for antiproliferative effects using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. The derivatives 4-allylbenzene-1,2-diol (3), 4 4-[3-(acetyloxy)propyl]-1,2-phenylene diacetate (6) and 4-[3-(acetyloxy)propyl]- 5-nitro-1,2-phenylene diacetate (10) showed higher cytotoxicity than the parent compound 2 in tests performed on two breast cancer cell lines (MCF-7 and MDA-MB-231). The IC50 values of 40.2 ± 6.9 μM, 5.9 ± 0.8 μM and 33.8 ± 4.9 μM, respectively, were obtained without toxicity towards dermal human fibroblast (DHF cells).

Hair dyeing composition containing an aryldiamine and a substituted catechol

A composition for use in the dyeing of keratinous fibre such as hair includes an aqueous anaerobic solution of an aryldiamine and a substituted catechol. Optionally, an aromatic coupling agent can also be incorporated in the composition to modify the shade of color produced. Anaerobic storage conditions can, for example, be maintained by packing the composition in an aerosol container with a halocarbon propellant.

Asymmetric macrocycles containing oxygen and binaphthyl ring members

Chiral, hinged and functionalized host multiheteromacrocycles of the oxygen, nitrogen and sulfur-containing type are disclosed possessing holes sized to afford selective complexation of specific guest substances and shapes to recognize chirally guest molecules by virtue of the chiral steric barrier of the 2,2'-diheteroatom-1,1'-binaphthyl grouping, the naphthyl-naphthyl dihedral angle, and the provision of ortho positioned side chain substituents (arms) bearing terminal functional groups which act as counterions or additional complexing sites, and the provision of remote position side chain substituents used to control solubility and volatility properties or to bond the multiheteromacrocycles to solid supports.