46118-02-9Relevant articles and documents
Very long-chain phenylpropyl and phenylbutyl esters from Taxus baccata needle cuticular waxes
Jetter, Reinhard,Klinger, Adelheid,Sch?ffer, Stefanie
, p. 579 - 587 (2002)
The cuticular wax of Taxus baccata L. needles was found to contain four different classes of long-chain esters that were identified by various chemical transformations with product assignment employing GC-MS. Homologous series of (1) 3-(4′-hydroxyphenyl)-propyl esters of C20-C36 fatty acids, (2) 4-(4′-hydroxyphenyl)-2-butyl esters of C18-C28 fatty acids, (3) 3-(3′,4′-dihydroxyphenyl)-propyl esters of C20-C32 fatty acids, and (4) 4-(3′,4′-dihydroxyphenyl)-2-butyl esters of C18-C28 fatty acids were identified. The four compound classes amounted to 0.1-3.6 μg/cm2 of needle surface area, corresponding to 0.2-7.6% of the wax mixture, respectively. While both phenylpropyl ester series had a maximum for the homolog containing tetracosanoic acid, in the phenylbutyl esters homologs containing eicosanoic and docosanoic acids predominated.
Design, synthesis and biological evaluation of small molecular polyphenols as entry inhibitors against H5N1
Yang, Jian,Yang, Jing Xiang,Zhang, Fang,Chen, Gang,Pan, Wei,Yu, Rui,Wu, Shuwen,Tien, Po
, p. 2680 - 2684 (2014/06/09)
To find novel compounds against H5N1, three series of known or novel small molecular polyphenols were synthesized and tested in vitro for anti-H5N1 activity. In addition, the preliminary structure-antiviral activity relationships were elaborated. The results showed that some small molecular polyphenols had better anti-H5N1 activity, and could serve as novel virus entry inhibitors against H 5N1, likely targeting to HA2 protein. Noticeably, compound 4a showed the strongest activity against H5N1 among these compounds, and the molecular modeling analysis also suggested that this compound might target to HA2 protein. Therefore, compound 4a is well qualified to serve as a lead compound or scaffold for the further development of H 5N1 entry inhibitor.
Synthesis and structure/antioxidant activity relationship of novel catecholic antioxidant structural analogues to hydroxytyrosol and its lipophilic esters
Bernini, Roberta,Crisante, Fernanda,Barontini, Maurizio,Tofani, Daniela,Balducci, Valentina,Gambacorta, Augusto
experimental part, p. 7408 - 7416 (2012/10/08)
A large panel of novel catecholic antioxidants and their fatty acid or methyl carbonate esters has been synthesized in satisfactory to good yields through a 2-iodoxybenzoic acid (IBX)-mediated aromatic hydroxylation as the key step. The new catechols are
