13620-82-1

Basic information

• Product Name: Allylpyrocatechol -3,4-diacetate
• Synonyms: Allylpyrocatechol -3,4-diacetate;4-Allyl-1,2-diacetoxybenzene;4-Allylpyrocatechol diacetate;1,2-Diacetoxy-4-allylbenzene;4-(2-Propenyl)-1,2-benzenediol 1,2-diacetate;4-Allylcatechol diacetate
• CAS NO: 13620-82-1
• Molecular Formula: C₁₃H₁₄O₄
• Molecular Weight: 264.23078
• Mol File: 13620-82-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 310.4°Cat760mmHg
• Flash Point: 148℃
• Appearance: /
• Density: 1.120
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Allylpyrocatechol -3,4-diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Allylpyrocatechol -3,4-diacetate(13620-82-1)
• EPA Substance Registry System: Allylpyrocatechol -3,4-diacetate(13620-82-1)

Safety Data

• Hazardous Substances Data: 13620-82-1(Hazardous Substances Data)

Usage

General Description

Allylpyrocatechol-3,4-diacetate is a chemical compound derived from pyrocatechol, a type of phenol. It is formed through the acetylation of allylpyrocatechol, resulting in the formation of acetate esters at the 3 and 4 positions on the pyrocatechol ring. Allylpyrocatechol -3,4-diacetate is often used in the synthesis of pharmaceuticals, dyes, and fragrances, as well as in organic reactions to introduce aromatic functionalities. Its unique chemical structure and properties make it a valuable precursor in the production of various compounds with applications in different industries. Additionally, allylpyrocatechol-3,4-diacetate may also have potential biological activities and pharmacological properties, although further research is needed to fully understand its potential uses in medicine and other fields.

Upstream product

• 1125-74-2 3-(2-propenyl)-1,2-benzenediol 
• 75-36-5 acetyl chloride 
• 97-53-0 4-allylguaiacol 
• 94-59-7 1-allyl-3,4-methylenedioxybenzene 
• 1126-20-1 2-allyloxyphenol 
• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 1126-61-0 4-allylpyrocatechol 
• 108-24-7 acetic anhydride 

Downstream Products

• 46118-02-9 3-(3',4'-dihydroxyphenyl)-1-propanol 
• 147000-27-9 4-[3-(acetyloxy)propyl]-1,2-phenylene diacetate 
• 89266-70-6 4-propyl-1,2-phenyl diacetate 
• 1579274-04-6 4-(2,3-dihydroxypropyl)-1,2-phenylene diacetate 
• 141632-15-7 (E)-3-(3,4-dihydroxyphenyl)acrylaldehyde 
• 402761-80-2 (E)-4-(3-oxoprop-1-en-1-yl)-1,2-phenylene diacetate 

Relevant articles and documents

DDQ-mediated oxidation of allylarenes: Expedient access to cinnamaldehyde-containing phenylpropanoids

Phenylpropanoid natural products containing a cinnamaldehyde motif were easily synthesized from allylarenes mediated by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) oxidation. Representative examples described herein are five types of 4-hydroxycinnamaldehyde derivatives from monolignols biosynthesis, Boropinal C, and 7-methoxywutaifuranal from plant extracts. Especially, simple synthesis of 7-methoxywutaifuranal was exploited through selective mono-oxidation and subsequent isomerization-ring-closing-metathesis strategy.

Synthesis and evaluation of antiproliferative activity of a novel series of hydroxychavicol analogs

We have recently demonstrated that hydroxychavicol is a major constituent and the most active biophenolic of Piper betel leaves with significant antiproliferative activity in the micro molar range. Herein we present the design, synthesis and evaluation of fifteen novel hydroxychavicol analogs with varying antiproliferative activities in cancer cell lines from two representative tissue types, namely, the prostate and cervix that show very encouraging results compared to the parent compounds. Our long range goal is to develop a structure-activity guided relationship to gain mechanistic insights into novel molecular targets of this class of bioactive molecules for rational drug development. Cytotoxicity-guided experimentation on these novel analogs yielded the following structural factors as the key activity regulators: 1) unlike the hydroxyl substituent at position-4, the position-3 hydroxyl is vital for enhanced activity 2) acetoxyl groups are dispensable for activity as corroborated earlier by others 3) allylic double bonds at 2′C-3′C serve to positively influence antiproliferative activity 4) long saturated side chains at 1′-position negatively regulate antiproliferative activity and 5) maneuvering position-4 with a benzyl group positively impacted the biological activity profile. Most amphiphilic compounds showed moderate to good therapeutic potential as expected on the basis of medicinal chemistry principles. Intriguingly, the most active compound with ten-fold higher activity than the parent molecule was realized by sheer serendipity to employ a silica gel based rearrangement that was further explored using nuclear magnetic resonance spectroscopy and density functional theory calculations. This is the first report to describe strategies for optimal synthesis of a novel series of 15 analogs based upon hydroxychavicol, a simple phytochemical of immense anticancer potential.

INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO)

The present invention relates to compounds of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.