461406-52-0

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 4039-83-2 3-(4-methoxybenzyloxy)propyne 
• 79-22-1 methyl chloroformate 

Downstream Products

• 1013326-37-8 (Z)-methyl 4-(4-methoxybenzyloxy)-3-methylbut-2-enoate 
• 1426310-05-5 (E)-methyl 3-(3-(tert-butyldimethylsilyloxy)propoxy)-4-(4-methoxybenzyloxy)but-2-enoate 
• 1426310-11-3 (R,E)-methyl 3-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-4-(4-methoxybenzyloxy)but-2-enoate 
• 1426310-06-6 (E)-methyl 3-(3-hydroxypropoxy)-4-(4-methoxybenzyloxy)but-2-enoate 
• 1426310-07-7 (E)-methyl 4-(4-methoxybenzyloxy)-3-(3-oxopropoxy)but-2-enoate 
• 1426310-10-2 methyl 2-(2-((4-methoxybenzyloxy)methyl)-3-oxo-tetrahydrofuran-2-yl)acetate 
• 1426310-12-4 (S,E)-methyl 3-(2,3-dihydroxypropoxy)-4-(4-methoxybenzyloxy)but-2-enoate 
• 1426310-13-5 (R,E)-methyl 3-(2,3-bis(tert-butyldimethylsilyloxy)propoxy)-4-(4-methoxybenzyloxy)but-2-enoate 
• 1426310-14-6 (S,E)-methyl 3-(2-(tert-butyldimethylsilyloxy)-3-hydroxypropoxy)-4-(4-methoxybenzyloxy)but-2-enoate 
• 1426310-16-8 (R,E)-methyl 3-(2-(tert-butyldimethylsilyloxy)-3-oxopropoxy)-4-(4-methoxybenzyloxy)but-2-enoate 
• 1426310-17-9 (3aR,6R,6aS)-6-(tert-butyldimethylsilyloxy)-3a-((4-methoxybenzyloxy)methyl)tetrahydrofuro[3,2-b]furan-2(5H)-one 
• 1426310-18-0 methyl 2-((2R,3R,4R)-4-(tertbutyldimethylsilyloxy)-3-hydroxy-2-((4-methoxybenzyloxy)methyl)-tetrahydrofuran-2-yl)acetate 
• 1426310-22-6 (2R,3R,4R)-4-(tert-butyldimethylsilyloxy)-2-(2-methoxy-2-oxoethyl)-2-((4-methoxybenzyloxy)methyl)tetrahydrofuran-3-yl hexanoate 
• 1388732-48-6 C₂₀H₃₃N₃O₅Si 

Relevant academic research and scientific papers

Ketyl radical cyclization of β-disubstituted acrylates: Formal syntheses of (+)-secosyrin 1 and longianone and the total synthesis of (+)-4-epi-secosyrin 1

A novel approach to the synthesis of a series of 1,7-dioxaspirononanes that applies a ketyl radical cyclization strategy is described. Radical cyclization of the β-disubstituted acrylate 23, prepared in five steps from (R)-1,2-isopropylideneglycerol, gives both 2,3-syn- and 2,3-anti-furan products. The densely functionalized furan heterocycles are used to complete a concise formal synthesis of secosyrin 1, a metabolite of Pseudomonas syringae, and the total synthesis of 4-epi-secosyrin 1.

Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids

The absolute configuration (via degradation and Marfey's derivatization studies) and the total synthesis of a novel antimalarial lipid-peptide isolated from Streptomyces sp. (IC50 = 0.8 μM, Plasmodium falciparum 3D7) is disclosed. To this end, versatile stereocontrolled routes to nonproteinogenic amino acids (via catalytic Mannich, Sharpless methods) and enantiomeric trans fatty acids (via Evans alkylation, Kocienski-Julia olefination) have been developed.

Synthesis of enantiopure 2-C-methyl-d-erythritol-4-phosphate

The synthesis of enantiopure 2-C-methyl-d-erythritol-4-phosphate is disclosed. A 1,3-diol possessing a quaternary stereogenic centre, prepared stereoselectively from an acyclic tri-substituted alkene, has been utilized as a key intermediate.

Studies aimed at the total synthesis of azadirachtin. A modeled connection of C-8 and C-14 in azadirachtin

(figure presented) Studies on the connection between the right and left segments of azadirachtin are described. The Ireland-Claisen rearrangement of Li-enolate of the modeled ester with dichlorodimethylsilane in toluene afforded the desired limonoid frame