461648-39-5Relevant articles and documents
Preparation method of umeclidinium bromide intermediate
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Paragraph 0035; 0037; 0041; 0043; 0052, (2021/04/14)
The invention relates to a preparation method of an umeclidinium bromide intermediate. The preparation method comprises the following steps: in a solvent, carrying out cyclization reaction on a compound as shown in a formula I, and conducting salifying wi
1 - Azabicyclo [2, 2, 2] octan -4 -phenyl ketone compound as well as preparation method and application thereof
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, (2021/03/17)
The invention provides 1-bicyclic aza[2,2,2]octyl-4-phenyl ketone compound as well as a preparation method and application thereof. Proofed by detection, the structure of the 1-bicyclic aza[2,2,2]octyl-4-phenyl ketone compound is a compound 1. The compound can be used for preparing an umeclidinium bromide medicine for treating COPD (chronic obstructive pulmonary disease), namely that 1-(2-chloroethyl ethyl)-4-benzoyl piperidine is prepared by 4-benzoyl piperidine, and then is subject to ring closing to obtain the compound 1; the compound 1 is further added with a phenyl nucleophilic reagent, and is salted, so as to obtain the umeclidinium bromide. The preparation method has the advantages that the cost is low, the operation is simple and convenient, the preparation method is suitable for industrial production, and the application value is larger. (The formula is shown in the description.).
A More Sustainable Process for Preparation of the Muscarinic Acetylcholine Antagonist Umeclidinium Bromide
Espadinha, Margarida,Louren?o, Nuno M. T.,Sobral, Luis,Antunes, Rafael,Santos, Maria M. M.
, p. 2053 - 2056 (2018/09/20)
A more sustainable process for the synthesis of the long-acting muscarinic acetylcholine antagonist umeclidinium bromide is described. Specifically, we report the synthesis of ethyl 1-(2-chloroethyl)-4-piperidinecarboxylate, a key intermediate in the prep