461665-75-8Relevant academic research and scientific papers
A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1′ group for the β-amino hydroxamic acid derived TACE inhibitors
Chen, Xiao-Tao,Ghavimi, Bahman,Corbett, Ronald L.,Xue, Chu-Biao,Liu, Rui-Qin,Covington, Maryanne B.,Qian, Mingxin,Vaddi, Krishna G.,Christ, David D.,Hartman, Karl D.,Ribadeneira, Maria D.,Trzaskos, James M.,Newton, Robert C.,Decicco, Carl P.,Duan, James J.-W.
, p. 1865 - 1870 (2007/10/03)
A new P1′ group for TACE inhibitors was identified by eliminating the oxygen atom in the linker of the original 4-(2-methylquinolin-4-ylmethoxy)phenyl P1′ group. Incorporation of this 4-(2-methylquinolin-4-ylmethyl)phenyl group onto different β-aminohydro
Barbituric acid derivatives as inhibitors of TNF-alpha converting enzyme (TACE) and/or matrix metalloproteinases
-
Page/Page column 33, (2008/06/13)
The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, U
