461704-75-6Relevant academic research and scientific papers
Synthesis and antimicrobial activities of novel formazans incorporating pyrimidine ring
Goudgaon,Upendar Reddy
experimental part, p. 617 - 623 (2010/07/03)
Reaction of 5-substituted-4(3H)-one-2-mercaptopyrimidines 1a and 1b with hydrazine hydrate furnishes 5-substituted-4(3H)-one-2-hydrazinopyrimidines 2a and 2b. Condensation of compounds 2a and 2b with salicylaldehyde and anisaldehyde yields 2-hydroxybenzaldehyde-(5′-substituted- 4′(3′H)-one)-2′-pyrimidazolylhydrazones) 3a and 3b and 4-methoxybenzaldehyde-(5′-substituted-4′(3′H)-one) -2′-pyrimidazorylhydrazones) 3c and 3d respectively. Compounds 3a-d were reacted with diazonium salts of an appropriate primary amine in presence of base furnished the target formazans 4a-1. All the synthesized compounds were evaluated for antimicrobial activities.
